Denigma

Interventions

  • Species: + -
    House mouse « 
  • Manipulation: + -
    Overexpression «  Gain‑of‑Function (26)   Loss‑of‑Function (1)   Mutation (2)   Deletion (1)   Gene Therapy (1)  
    • name effect species mean median maximum
    Tert overexpression Mice genetically modified to express telomerase lived 40% longer and do not develop cancer. Overexpression of Tert in mice engineered to be cancer-resistant by means of ehanced expression of p53, p16 and p19ARF (Sp53/Sp16/SARF/TgTERT) decreased telomere shortening with age, delayed aging and increases mean and median longevity by 40% [19013273]. Mouse +40 +40 —
    Sirt6 overexpression Overexpression of Sirt6 in male mice lengthens the median lifespan by 9.9-14.5% and maximum lifespan by 13.1-15.8% [22367546]. Mouse — +9.9 to +14.5 +13.1 to +15.8
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    • 2 of 27 interventions
    Interventions are an extension of GenAge and GenDR.