Denigma: Interventions

Interventions

Fruit fly «

Mutation « Knockdown « Loss‑of‑Function (1)

name	effect	species	mean	median	maximum
Heterozygous hypomorphic Rpd3 mutation	Males heterozygous for hypomorphic (partial loss-of-function) mutation of Rpd3 have a lifespan extension of 33%. Females heterozygous for a hypomorphic allele have a 52% increase in lifespan. Longevity increases to the same extent in wild-type under low-calorie diet and rpd3 mutants fed normal diet [12459580].	Fly	+33 to 52	—	—

Interventions are an extension of

GenDR.