| AVO2 deletion | Deletion of AVO2 extends chronological lifespan [21641548]. | Yeast | — | — | — |
| AGP1 deletion | Deletion of AGP1 extends chronological lifespan [16418483]. | Yeast | — | — | — |
| FOB1 deletion | Mutation in FOB1 extends replicative lifespan by 30-50% [10230397]. FOB1 mutation increases replicative lifespan by 25% in the alpha strain and by 10% in a strain [19030232]. FOB1 mutant exhibit an about 20% mean replicative lifespan increase [15722108]. Deletion of FOB1 causes extension in the short life span of the sir2 mutant by around 50% [10521401]. Mutation of the FOB1 gene slows the generation of rDNA circles and thus extends life span by approximately 30% in W303 and 50% in K2307 [10230397]. Even in cells lacking both Sir2 and Fob1, nicotinamide prevents the lifespan extension by DR [16311627]. | Yeast | — | — | — |
| CSR2 deletion | Deletion of CSR2 results in higher levels of intracellular reactive oxygen species, augmentation of scavenging enzymes and extends replicative as well as chronological lifespan [16336970]. | Yeast | — | — | — |
| ATG7 deletion | ATG7 deletion reduces chronological lifespan by 70% [19302372]. | Yeast | — | — | — |
| FBP1 deletion | Deletion of FBP1 increases survival during the first 15 days during chronologocal aging, but does not increase chronological lifespan. FBP1 deletion reduces production of reactive oxygen species [16199065]. | Yeast | — | — | — |
| VPS8 deletion | Lack of VPS8 reduces lifespan under starvation conditions to a level similiar to that of wild-type cells incubated in synthetic complete medium and therefore blocked the lifespan-extending effect of DR [20657825]. | Yeast | — | — | — |
| VPS27 deletion | Under starvation conditions VPS27 deletion mutants have a dramatically reduced lifespan [20953148]. | Yeast | — | — | — |
| GCN5 deletion | Deletion of GCN5 decreases replicative lifespan of extension of rho+ and rho0 cells as well as suppresses lifespan extension by the retrograde response [15547318]. Deletion of GCN5 strongly reduces chronological lifespan [19801973]. | Yeast | — | — | — |
| ACH1 deletion | ACH1 deletion cells accumulate a high amount of extracellular acetic acid and display a reduced mean and maximum chronological lifespan. Maximum lifespan is reduced by 32%. Lifespan shortening is completely abrogated by alleviating the acid stress either by a DR regimen that prevents acetic acid production or by transferring chronologically aging mutant cells to water. Deletion of ACH1 is accompanied by reactive oxygen species accumulation, severe mitochondrial damage, and an early insurgence of apoptosis [22754872]. | Yeast | — | — | -32 |
| ISC1 deletion | ISC1 deletion decreases chronological lifespan [21707788; 21707788]. CTA1
overexpression partially suppresses the shortened lifespan by ISC1. Deletion of SIT4 totally rescues the short lifespan of ISC1 mutants [21707788]. HOG1 deletion partially suppresses the premature aging phenotype and short lifespan of ISC1 deletion [22445853]. | Yeast | — | — | — |
| HDA1 deletion | Deletion of HDA1 has no effect on longevity under AL, but acts synergistically with 0.1% glucose restriction to increase replicative lifespan [12213553]. Deletion of HDA1 leads to a slightly increased chronological lifespan [19801973]. Deletion of HDA1 has no effect on the wild-type lifespan in the short-lifespan of YSK771 strain, but suppresses the short-lifespan of SIR3 mutants [10512855]. Null mutation results in increased telomeric silencing and increased histone acetylation [8962081]. | Yeast | — | — | — |
| YKU70 deletion | Deletion fo YKU70 shortens lifespan, but does not accelerate the normal aging process [10521401]. YKU70 null mutants are defective for non-homologous end-joining [8754818] and for telomeric silencing [9635192]. | Yeast | — | — | — |
| SIT4 deletion | SIT4 deletion slightly increases chronological lifespan and totally abolishes the lifespan shortening due to ISC1 deletion [21707788]. | Yeast | — | — | — |
| YKU80 deletion | Deletion of YKU80 shortens replicative lifespan, but does not accelerate the normal aging process [10521401]. YKU80 null mutant is defective for non-homologous end-joining [8754818] and for telomere silincing [9501103; 9635192] | Yeast | — | — | — |
| TEC1 deletion | Absence of TEC1 causes a significant shortened chronological lifespan, but does not block chronological lifespan extension by rapamycin [21840851]. | Yeast | — | — | — |
| KSS1 deletion | Deletion of KSS1 results in increased sensitivity to heat shock and oxidative stress and a 25% reduction in median chronological lifespan [17662940]. | Yeast | — | -25 | — |
| HSC82 deletion | Deletion of HSC82 has no effect on replicative lifespan, but shortens chronological lifespan [11361336]. | Yeast | — | — | — |
| MEC1 deletion | MEC1 mutants have a 3-fold reduced mean and maximum chronological lifespan under conditions of medium depletion [17710147]. | Yeast | — | — | — |
| MEP2 deletion | Deletion of MEP2 extends chronological lifespan [16418483]. | Yeast | — | — | — |
| MEP3 deletion | Deletion of MEP3 extends chronological lifespan [16418483]. | Yeast | — | — | — |
| HES1 deletion | Deletion of HES1 (alias OSH5) extends mean replicative lifespan by 27% and is non-addative with moderate DR. Deletion of OSH5 delays different steps of endocytosis, a sterol-requireing process. [Xia et al., unpublished]. | Yeast | — | — | — |
| ATG18 deletion | The replicative lifespan of ATG18 deletion mutant is not shorter than that of wild-type under DR [18690010]. | Yeast | — | — | — |
| MXR2 deletion | Deletion of MXR2 (alias MsrB) has no effect on replicative lifespan under normal growth conditions, but simulatonous deletion of MXR2 together with MXR1 dramatically reduces replicative lifespan by 63% [15141092]. | Yeast | — | — | — |
| NDI1 deletion | Deletion of NDI1 results in chronological lifespan extension [16436509]. | Yeast | — | — | — |
GenAge
GenDR
