| daf-12 mutation | Mutations in daf-2 and daf-12, but not mutations in daf-12 alone, nearly quadruples lifespan [7789761]. Recessive loss of function mutation in daf-12 shortens lifespan. daf-12 activity is required for lifespan extension after germ line ablation [10360574]. daf-12 mutation suppresses the lifespan extension by mutation in daf-28 [8807293]. daf-12 mutants are dauer defective and heterochronic [7219552]. Some daf-12 alleles exhibit synthetic lethality with mutation of age-1 [8807293] or daf-12 [1732156]. | Worm | — | — | — |
| tdp-1 mutation | tdp-1(ok803) mutation increases mean and maximum lifespan at 20 degree Celsius but not at 25 degree Celsius. tdp-1(ok803) reduce the lifespan of daf-2(e1370) mutants, but does not does not reduces the lifespan of daf-16(mu86) mutants [Vaccaro et al. 2012]. | Worm | — | — | — |
| unc-1 mutation | Mutation in unc-1 has no effect on lifespan [9789046] | Worm | — | — | — |
| daf-18 mutation | daf-18 is required for complete dauer formation. daf-18 mutation partially suppresses the lifespan extension of age-1 and daf-2 mutants. daf-18 mutants are defective for dauer formation and form some dauer-like larvae when starved [7789761; 8601482]. | Worm | — | — | — |
| unc-15 mutation | Mutation of unc-15 has no effect on lifespan [9789046].
Some alleles of un-15 display severe paralysis [4366476; 2051482]. | Worm | — | — | — |
| unc-2 mutation | Loss of function in unc-2 has no effect on lifespan [9789046].
unc-2 mutant is uncoordinated [4366476] and its rate of pharyngeal pumping is reduced [8325482]. | Worm | — | — | — |
| unc-20 mutation | Mutation in unc-20 has no effect on lifespan [9789046].
unc-20 mutant is uncoordinated [4366476]. | Worm | — | — | — |
| daz-1 mutation | Mutation of daz-1 has no effect on lifespan [11799246]. daz-1 mutants are sterile and have a gonad that contains small nuclei and no oocytes [10662646]. Although sperm production is normal, oocytes precursors arrest at meiotic prophase and undergo apoptosis | Worm | — | — | — |
| unc-25 mutation | Mutations in unc-25 have no effect on lifespan [9789046].
unc-25 mutants are defective for foraging, locomotion, and defecation [8332190] as well as uncoordinated [4366476]. | Worm | — | — | — |
| unc-29 mutation | Mutation in unc-29 has no effect on lifespan [9789046] and fails to extend male lifespan [10747056].
unc-29 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-30 mutation | Mutations in unc-30 have no significant effect on lifespan [9789046].
unc-30 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-35 mutation | unc-35(e259) has no effect on male or hermaphrodite lifespan [10747056].
unc-35 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-10 mutation | Mutation in unc-10 reduces maximum lifespan 35% [17592521]. | Worm | — | — | -35 |
| unc-46 mutation | unc-46(e177) allele has no significant effect on lifespan [9789046].
unc-46 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-47 mutation | The unc-47(e367) allele has no significant effect on lifespan [9789046].
unc-47 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-54 mutation | Mutation in unc-54 has no effect on lifespan [9789046].
unc-54 mutants are paralyzed [4366476]. | Worm | — | — | — |
| unc-6 mutation | Mutation in unc-6 has no effect on lifespan [9789046].
unc-6 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-78 mutation | Mutation in unc-78 has no effect on lifespan [9789046].
unc-78 mutants move slowly [7190524]. | Worm | — | — | — |
| eat-10 mutation | The eat-10(ad606) allele exhibits no significant extension of lifespan [9789046], but displays defects in pharyngeal feeding behaviour [8462849]. | Worm | — | — | — |
| unc-79 mutation | The unc-79(e1068) allele has no significant effect on lifespan [9789046].
unc-78 mutants display irregular movement [4366476]. | Worm | — | — | — |
| unc-80 mutation | The unc-80(e1069) allele has no significant effect on lifespan [9789046].
unc-80 mutant displays irregular movement [4366476] | Worm | — | — | — |
| eat-5 mutation | The eat-5(ad464) allele has no significant effect on lifespan [9789046], although it displays defects in pharyngeal feeding behaviour [8462849]. | Worm | — | — | — |
| Coq7 overexpression | Transgenic overexpression of mouse Coq7 reverts the extended lifespan of clk-1 mutants [11511092]. | Worm | — | — | — |
| kri-1 mutation | kri-1(ok1251) mutation does not shorten the lifespan significantly [22560223]. | Worm | — | — | — |
| rsks-1 mutation | rsks-1 deletion mutants also live longer. TOR RNA interference further extends lifespan of rsks-1 mutants [17266679]. | Worm | — | — | — |
GenAge
GenDR
