Denigma

Interventions

  • Species: + -
    House mouse « 
  • Manipulation: + -
    Overexpression «  Gain‑of‑Function (26)   Loss‑of‑Function (1)   Mutation (2)   Deletion (1)   Gene Therapy (1)  
    • name effect species mean median maximum
    Tert overexpression Mice genetically modified to express telomerase lived 40% longer and do not develop cancer. Overexpression of Tert in mice engineered to be cancer-resistant by means of ehanced expression of p53, p16 and p19ARF (Sp53/Sp16/SARF/TgTERT) decreased telomere shortening with age, delayed aging and increases mean and median longevity by 40% [19013273]. Mouse +40 +40 —
    Pcmt overexpression Overexpression of Pcmt extends lifespan by 32-39% at 29 degrees but not at 25 degrees [11742076]. The adult lifespan of animals overexpressing Pcmt is extended [18772467]. Mouse 0 to 39 — —
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    • 2 of 27 interventions
    Interventions are an extension of GenAge and GenDR.