| daf-8 mutation | daf-8 mutation in adults increases mean lifespan by 9-31% but it did not increase maximum lifespan [17900898]. | Worm | +9 to +31 | — | — |
| daz-1 mutation | Mutation of daz-1 has no effect on lifespan [11799246]. daz-1 mutants are sterile and have a gonad that contains small nuclei and no oocytes [10662646]. Although sperm production is normal, oocytes precursors arrest at meiotic prophase and undergo apoptosis | Worm | — | — | — |
| unc-25 mutation | Mutations in unc-25 have no effect on lifespan [9789046].
unc-25 mutants are defective for foraging, locomotion, and defecation [8332190] as well as uncoordinated [4366476]. | Worm | — | — | — |
| unc-26 mutation | Mutations in unc-26 extend lifespan by 30-50%. Lifespan extension is proposed to be similar to DR [9789046].
unc-26 mutants are uncoordinated, slow and have defects in pharyngeal pumping [4366476; 8462849]. | Worm | +30 to +50 | — | — |
| unc-29 mutation | Mutation in unc-29 has no effect on lifespan [9789046] and fails to extend male lifespan [10747056].
unc-29 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-30 mutation | Mutations in unc-30 have no significant effect on lifespan [9789046].
unc-30 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-31 mutation | Mutation in unc-31 increases hermaphrodite lifespan by approximately 70% and male lifespan by 150% [10377425; 11063684; 10747056]. unc-31 also cause constitutive dauer formation. Both phenotypes, enhanced longevity and constitutive dauer formation are suppressed by mutations in daf-16 [10377425].
unc-31 mutants are uncoordinated [4366476] and exhibit dauer constitutive phenotype [10377425], are lethargic, feed constitutively, are defective in egg-laying, and produce dauer larvae that fail to recover [8462849]. | Worm | +70 to +150 | — | — |
| unc-32 mutation | unc-32 mutation extends male lifespan by about 170%, but has no effect on hermaphrodite lifespan [10747056].
unc-31 mutants are uncoordinated [4366476]. | Worm | +170 | — | — |
| unc-35 mutation | unc-35(e259) has no effect on male or hermaphrodite lifespan [10747056].
unc-35 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-4 mutation | Mutation in unc-4 has no significant effect on hermaphrodite lifespan [9789046]. Lifespan of unc-4(e120) males is extended relative to hermaphrodites approximately 2-fold [10747056].
unc-4 mutants are uncoordinated [4366476]. | Worm | +100 | — | — |
| unc-46 mutation | unc-46(e177) allele has no significant effect on lifespan [9789046].
unc-46 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-47 mutation | The unc-47(e367) allele has no significant effect on lifespan [9789046].
unc-47 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-54 mutation | Mutation in unc-54 has no effect on lifespan [9789046].
unc-54 mutants are paralyzed [4366476]. | Worm | — | — | — |
| unc-6 mutation | Mutation in unc-6 has no effect on lifespan [9789046].
unc-6 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-64 mutation | Mutations in unc-64 result in constitutive dauer formation and increase lifespan, which is suppressed by mutations in daf-16 [10377425]. unc-64 mutation increases mean and maximum lifespan [16280150]. unc-64 mutation increased lifespan of hermaphrodites by approximately 70% and those of males by 150% [10377425; 4366476; 10747056].
unc-64 mutants are uncoordinated [4366476]. | Worm | +70 to +150 | — | — |
| unc-76 mutation | unc-76(e911) allele extends male lifespan by about 50%, but has no effect on hermaphrodite lifespan [10747056].
unc-76 mutants are uncoordinated [4366476]. | Worm | +50 | — | — |
| eat-1 mutation | Loss-of-function mutations in eat-1 extend lifespan byy 10-30%. Lifespan extension is proposed to be similar to DR [9789046]. eat-1 mutants have defects in pharyngeal feeding behavior [8462849]. | Worm | +10 to +30 | — | — |
| unc-78 mutation | Mutation in unc-78 has no effect on lifespan [9789046].
unc-78 mutants move slowly [7190524]. | Worm | — | — | — |
| eat-10 mutation | The eat-10(ad606) allele exhibits no significant extension of lifespan [9789046], but displays defects in pharyngeal feeding behaviour [8462849]. | Worm | — | — | — |
| Overexpression of constitutive nuclear SKN-1 | skn-1 transgenes that overexpress a constitutive nuclear form of SKN-1 in the intestine extend the mean lifespan by 5-21%, independently of DAF-16 [18358814]. | Worm | +5 to +21 | — | — |
| eat-13 mutation | The eat-13(ad522) allele extends lifespan by 30%. Extension of lifespan is proposed to be similar to DR [9789046]. eat-1 mutants have defects in pharyngeal feeding behavior [8462849]. | Worm | +30 | — | — |
| unc-79 mutation | The unc-79(e1068) allele has no significant effect on lifespan [9789046].
unc-78 mutants display irregular movement [4366476]. | Worm | — | — | — |
| daf-15 mutation | Mutations in daf-15 (raptor) extends adult lifespan by 15-30% in a daf-16 dependent manner. daf-15 mutation are dauer defective [15253933]. | Worm | +15 to +30 | — | — |
| eat-18 mutation | Mutations in eat-18 extend lifespan by 15-60%. Lifespan extension is proposed to be similar to DR [9789046]. eat-1 mutants have defects in pharyngeal feeding behavior [8462849]. | Worm | +15 to +60 | — | — |
| unc-80 mutation | The unc-80(e1069) allele has no significant effect on lifespan [9789046].
unc-80 mutant displays irregular movement [4366476] | Worm | — | — | — |
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