Denigma

Interventions

  • Species: + -
    House mouse « 
  • Manipulation: + -
    Overexpression «  Gain‑of‑Function (26)   Loss‑of‑Function (1)   Mutation (2)   Deletion (1)   Gene Therapy (1)  
    • name effect species mean median maximum
    Bub1b overexpression Sustained high-level expression of BubR1 preserves genomic integrity and reduces tumorgenesis (even in the presence of genetic alterations that strongly promote aneuplodization and cancer, such as oncogenic Ras) and extends the lifespan and delays age-related deterioriation and aneuploidy in several tissues [23242215]. BubR1 overabundance exerts its protective effect by correcting mitotic checkpoints defects [23242215]. BubB1 overexpression extends maximum lifespan by 20 - 41% compared to GFP-carrying control transgenic mice [23242215]. Mouse — — +20 to +41.3
    TXN overexpression Overexpression of TXN1 in transgenic C57BL/6 mice resulted in extended median (35%) and maximum (22%) lifespan. Telomerase activity in spleen tissues of TXN1 overexpressing mice is higher than tha in wild-type [12230882]. Mouse — +35 +22
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    • 2 of 27 interventions
    Interventions are an extension of GenAge and GenDR.