| RAS1 deletion | Deletion in RAS1 increases mean (23%) and maximum (29%) replicative lifespan (in SP1) [8034612]. RAS1 deletion increases replicative lifespan by 15% in the alpha strain [19030232]. However, deletion of RAS1 slightly shortens chronological lifespan (in SP1) [12586694]. | Yeast | +15 to +23 | — | +29 |
| PAN2 deletion | Deletion mutant of PAN2 live approximately as long as wild-type under starvation/extreme DR [20657825]. | Yeast | — | — | — |
| ACO1 deletion | Deletion of ACO1 decreases mean chronological lifespan by 42 - 56% in diploid cells [21447998]. | Yeast | -42 to -56 | — | — |
| AGP1 deletion | Deletion of AGP1 extends chronological lifespan [16418483]. | Yeast | — | — | — |
| AKR1 deletion | Deletion of AKR1 decreases replicative lifespan by 40% in the alpha strain [18340043]. Replicative lifespan decreased by 50% in the alpha strain [19030232]. | Yeast | -40 to -50 | — | — |
| ANS1 deletion | Deletion of ANS1 decreases replicative lifespan by 25% in the alpha strain [19030232]. | Yeast | -25 | — | — |
| ARP1 deletion | Deletion of ARP1 decreases replicative lifespan by 40% in the alpha strain [18340043; 19030232]. | Yeast | -40 | — | — |
| ATG15 deletion | Deletion of ATG15 does not affect the lifespan significantly on AL, while DR shortens replicative lifespan of ATG15 deletion mutant by 28% [18690010]. | Yeast | — | — | — |
| ATH1 deletion | Deletion of ATH1 extend the mean chronological lifespan by 17% (at 30 degree Celsus in BY4742) [22783207].
ATH1 mutants have higher trehalose levels until the end of the post-diauxic growth phase, but reaches a plateau at the level of 50-70% of wild-type in the stationary phase [22783207]. | Yeast | +17 | — | — |
| ATP1 deletion | Deletion of ATP1 increases chronological lifespan by up to 50% [17492370], but decreases replicative lifespan by 70% in the alpha strain [18340043]. | Yeast | -70 to +50 | — | — |
| AVO2 deletion | Deletion of AVO2 extends chronological lifespan [21641548]. | Yeast | — | — | — |
| AVT1 deletion | Deletion of AVT1 accelerates the development of age-induced mitochondrial dysfunction without effecting the kinetics of vacuolar acidity decline and prevents the suppression of mitochondrial dysfunction by VMA1 and VPH2 overexpression without affecting vacuolar acidity. AVT1 deletion decreases mean, median and maximum lifespan by 21, 22, and 12%, respectively [23172144]. | Yeast | -20.6 | -22.4 | -11.8 |
| BAS1 deletion | Deletion of BAS1 increases replicative lifespan by 30% in the alpha strain [16293764; 19030232]. | Yeast | +30 | — | — |
| BNA6 deletion | Deletion of BNA6 (alias QPT1) has no effect on replicative lifespan and is not required for lifespan extension by DR, but is lethal with mutation of NPT1 [11000115]. Deletion of BNA6 decreases chronological lifespan [17110466]. | Yeast | — | — | — |
| BRE5 deletion | Deletion of BRE5 increases mean replicative lifespan by 30% [16293764] and mean chronological lifespan in diploid cells [21447998] | Yeast | +30 | — | — |
| BUL1 deletion | Deletion of BUL1 does non-significantly reduces mean chronological lifespan under starvation/extreme DR [20657825]. | Yeast | — | — | — |
| CAT5 deletion | Deletion of CAT5 decreases chronological lifespan by up to 50% [17492370] and also decreases replicative lifespan by 30% in the alpha strain [18340043]. | Yeast | -30 to -50 | — | — |
| CCR4 deletion | Deletion of CCR4 increases mean chronological lifespan by 20 - 41% (20, 33, 41) in diploid cells [21447998]. In W303R CCR4 deletion shortens replicative lifespan by approximately 80% and results in temperature sensitivity that is suppressed by SSD1-V. SSD1-V partially suppresses the short-lifespan of ccr4 mutant. CCR4 mutation is synthetically lethal in combination with deletion of MPT5 in the absence of SSD1-V [11805047]. | Yeast | -80 to +20 | — | — |
| CCS1 deletion | Deletion of CCS1 reduces replicative lifespan by 50% [17460215]. | Yeast | -50 | — | — |
| CIT2 deletion | Deletion of CIT2 has no effect on replicative lifespan [10224252]. | Yeast | — | — | — |
| CLA4 deletion | Deletion of CLA4 decreases replicative lifespan by 60% in the alpha strain [18340043; 19030232]. | Yeast | -60 | — | — |
| COQ3 deletion | Deletion of COQ3 decreases chronological lifespan and renders cells respiratory deficient and sensitive to hydrogen peroxide [12586694]. | Yeast | — | — | — |
| CPR7 deletion | Deletion of CPR7 has no effect on lifespan replicative lifespan, but increases chronological lifespan [11361336] | Yeast | — | — | — |
| CRC1 deletion | Deletion of CRC1 increases replicative lifespan [16293764]. CRC1 deletion increases replicative lifespan by 25% in the alpha strain [19030232] | Yeast | +25 | — | — |
| CSR2 deletion | Deletion of CSR2 results in higher levels of intracellular reactive oxygen species, augmentation of scavenging enzymes and extends replicative as well as chronological lifespan [16336970]. | Yeast | — | — | — |
GenAge
GenDR
