| ry mutation | Loss-of-function mutation of ry reduces mean lifespan by 45% and maximum lifespan by 35% [17435236]. | Fly | -45 | — | -35 |
| g mutation | Loss-of-function mutation reduces mean lifespan by 11 - 42% and maximum lifespan by 7 - 30% [17435236]. | Fly | -11 to -42 | — | -7 to -30 |
| rb mutation | Loss-of-function mutation reduces mean lifespan by 33 and maximum lifespan by 22% [17435236]. | Fly | -33 | — | -22 |
| lt mutation | Loss-of-function mutation reduces mean lifespan by 47% and maximum lifespan by 10% [17435236]. | Fly | -47 | — | -10 |
| Heterzygous Rpd3 null mutation | Males heterozygous for a null mutation of Rpd3 have a lifespan extension of 41 - 47%. Females carrying a null mutation have only modest increase in maximum lifespan (but not median lifespan). Longevity increases to the same extent in wild-type under low-calorie diet and rpd3 mutants fed normal diet. DR fails to further increase lifespan of rpd3 mutants [12459580]. | Fly | +41 to +47 | — | — |
| Heterozygous hypomorphic Rpd3 mutation | Males heterozygous for hypomorphic (partial loss-of-function) mutation of Rpd3 have a lifespan extension of 33%. Females heterozygous for a hypomorphic allele have a 52% increase in lifespan. Longevity increases to the same extent in wild-type under low-calorie diet and rpd3 mutants fed normal diet [12459580]. | Fly | +33 to 52 | — | — |
| esc mutation | Males heterozygous for the null esc4 or the dominant negative esc9 mutation that are progeny of an out-cross to a O-R wild-type strain have median lifespan that is, respectively, 47% and 60% longer than the O-R control. When derived from an out-cross to a longer-lived C-S wild-type strain, heterozygous esc9 flies have a median lifespan that is 43% longer than the C-S control [20018689]. | Fly | +47 to +60 | — | +34 |
| Dcr-2 mutation | Median lifespan of homozyogous and transheterozyogous Dcr-2 mutants is reduced by 18-36% in males and by 27-36% in females. Dcr-2 loss changes the expression of mostly metabolic genes implicated in stress resistance and aging. Dcr-2 mutants are hypersensitive to oxidative, endoplasmic reticulum, starvation and cold stress as well as abnormal lipid and carbohydrate metabolism [21889502].
| Fly | -18 to -36 | — | — |
| EcR mutation | Mutant heterozygotes in EcR live on mean 40%-50% longer than controls [12610309; reviewed in 12610294]. Homozygous mutants in EcR are inviable. The developmental time and weight of EcR+/- mutants is the same as control, but resistance to temperature, oxidative stress, and starvation is increased in heterozygotes [12610309]. | Fly | +40 to +50 | — | — |
| sdhC dominant negative overexpression | Mutants expressing a dominant negative form of sdhC in the nervous system have a 22% reduced mean lifespan and signs of oxidative stress induction [17854771]. | Fly | -22 | — | — |
| mth mutation | Mutants in mth display approximately 35% and 36% increase in average and maximum lifespan as well as enhanced resistance to various forms of stress (including starvation, high temperature, and dietary paraquat) [9794765]. | Fly | +35 | — | +36 |
| Heterzygous chico mutation | Mutation in chico extends mean, median and maximum lifespan by 44%, 36% and 35% in heterozygotes. chico mutation produces dwarf, long-lived females at normal nutrition [11292874]. Wild-type and chico mutant females have similar peak lifespan under DR, but the food concentration at which these are achieved is shifted to higher amounts. chico mutation induces a state equivalent to submaximal, DR-induced slowing of aging [11951037]. Male chico heterozygous live 13% longer than wild-type [11292874]. chico heterzoygous females have a reduced fecundity. chico heterozygous mutants are resistant to starvation but not oxidative stress or temperature stress [11292874]. | Fly | +44 | +36 | +35 |
| Homozygous chico mutation | Mutation in chico extends mean, median, and maximum lifespan by 56%, 48%, and 42% in homozygotes. chico mutation produces dwarf, long-lived females at normal nutrition [11292874]. Wild-type and chico mutant females have similar peak lifespan under DR, but the food concentration at which these are achieved is shifted to higher amounts. chico mutation induces a state equivalent to submaximal, DR-induced slowing of aging [11951037]. Male chico homozygous have a shortened lifespan [11292874]. Female chico homozygous recessive mutants are sterile [11292874]. | Fly | +56 | +48 | +42 |
| egm mutation | Mutation in egm confers resistance to oxidative stress and extends the lifespan [16434470]. | Fly | — | — | — |
| snz mutation | Mutation in snz increases maximum lifespan of both sexes by up to 66%, while the median female lifespan is approximately 85% higher and that of males around 72% [18478054]. | Fly | — | +72 to +85 | +66 |
| Atg8a mutation | Mutations in Atg8a results in reduced lifespan and increased sensitivity to oxidative stress [18059160].
Atg8a mutation reduces the maximum lifespan by 25% under starvation conditions [17617737].
Loss-of-function mutation in atg8a reduces mean lifespan by 11 - 25% and maximum lifespan by 3 - 22% [17435236]. | Fly | -11 to -25 | — | -3 to -25 |
| InRE19/InRp5545 transheterozygous mutation | Mutations in InR (InRE19/InRp5545 transheterozygous) result in dwarf females with extended lifespan of up to 85% and dwarf males with reduced late age-specific mortality (although no significant change in lifespan) [11292875]. | Fly | +85 | — | — |
| mys Mutation | mys mutants exhibit ameliorated age-related declines in locomotor activity and an increase in mean lifespan of 20% [14570233]. | Fly | +20 | — | — |
| Thor mutation | Null mutation in Thor (alias d4E-BP) causes a significant decrease in longevity (-25% median lifespan in males). foxo (alias dFOXO) and Thor null mutants are compromised in stress resistant. Stress resistance of foxo null mutants is rescued by Thor overexpression [16055649]. Thor null mutants cancel out DR-induced lifespan extension, because mutants exhibit a diminished change in lifespan when nutrient conditions were varied. Thor null mutants have a wild-type similar reduction in egg production upon DR [19804760]. | Fly | — | -25 | — |
| Constitutive active S6k overexpression | Overexpression of a constitutively active form of S6k (alias dS6K) decreases mean lifespan by 34% at 29°C [15186745]. | Fly | -34 | — | — |
| pex16 mutation | pex16 mutation lead to a reduced mean lifespan of one-third in females and on-fourth in males. The short lifespan can be rescued by the simultaneous overexpression of pex16 in the fat body and differentiated neurons [21826223].
Mutant flies lack normal peroxisomes, have an reduced adult body size (70%-85% smaller than controls) and rozy eyes, show locomotion defects in the development of the nervous system [21826223]. | Fly | -33 to -75 | — | — |
| Rbp9 mutation | Rbp9 mutation significantly decreases longevity with a 33% reduction in median lifespan of males [20589912]. | Fly | — | -33 | — |
| Loco mutation | Reduced expression of Loco due to hetero-deficient results in a 17-20% longer mean lifespan for both male and females, besides the fact that the homozygous deficiency of loco is lethal. Several of these long-lived mutants are more resistant to stresses such as starvation, oxidation ad heat. Additional mutant have higher Manganese-containing superoxide dismutase (MnSOD) activity, increased fat content an diminished cAMP levels. Loco RGS domain is required for the regulation of longevity as deletion analysis suggest [21776417]. | Fly | +17 to +20 | — | — |
| rho-7 knockout | rho-7 knockout flies have severe neurological defects and a much reduced lifespan [16713954]. | Fly | — | — | — |
| DJ-1alpha RNAi | RNA interference of DJ-1alpha shortens maximum lifespan by 13% and results in increased sensitivity to oxidative stress and motor impairments [17651920]. | Fly | — | — | -13 |
GenAge
GenDR
