| daf-7 mutation | daf-7 mutation does not significantly change lifespan [8247153]. Mutations in daf-7 cause up to 50% mean and maximum life-extension. This effect is dependent upon daf-3 and on daf-16 but independent of daf-2. daf-7(e1372) increases mean and maximum lifespan by 13-39% and 55%, respectively. daf-7(m62) increases mean and maximum lifespan by 20-29% and 29% [17900898]. | Worm | +13 to +39 | — | +29 to +55 |
| daf-8 mutation | daf-8 mutation in adults increases mean lifespan by 9-31% but it did not increase maximum lifespan [17900898]. | Worm | +9 to +31 | — | — |
| pept-2 mutation | Deletion of pept-1 (alias opt-2 or pep-2) results in retarded development, reduced body size and extended reproductive lifespan. It also further extends (60%) the life-extension caused by daf-2 mutations [15155758].
pept-2 mutants exhibit a decrease in fat content. | Worm | — | — | — |
| PIB1 deletion | Deletion of PIB1 increases replicative lifespan by 25% in the alpha strain [16293764; 19030232]. | Worm | +25 | — | — |
| URE2 deletion | Deletion of URE2 increase mean replicative lifespan by 21-31% in BY4742 [16293764]. URE2 deletion increases replicative lifespan increased by 20% in the alpha strain [19030232]. | Worm | +20 to +31 | — | — |
| YLR460C deletion | Deletion of YLR460C decreases replicative lifespan by 30% in the alpha strain [19030232]. | Worm | -30 | — | — |
| eat-2 mutation | eat-2 mutations result in partial starvation by disrupting the function of the pharynx and an approximately 50% extension of lifespan. eat-2 mutants life significant longer by up to 57% [9789046]. eat-2(ad1116) mutants have an extended mean, 75%ile and maximum lifespan by 30, 35, and 24% [22810224]. sDR further increases the long lifespan of eat-2 mutants [19239417]. eat-2 mutants live longer than wild-type at high food concentration but are short lived at lower concentrations (via bacterial dilution) [19229346]. eat-2(ad1113) mutation increases mean lifespan by 56% and is non-additive with SCNA overexpression [16782295]. Combining eat-2 mutation with bacterial deprivation DR does not result in an additive increase in lifespan [17081160;17096674]. Loss of function of eat-2 extends lifespan by 20-30%. Lifespan extension is proposed to be similar to DR. eat-2;daf-2 double mutant live longer than daf-2 single mutants [9789046]. Therefore, eat-2 mutants can synergize with daf-2 mutants, but not with clk-1 mutants, for lifespan extension. Lifespan extension conferred by eat-2 is not suppressed by daf-16 mutation [9789046].
| Worm | +30 to +57 | — | +24 |
| egl-9 mutation | egl-9 deletion does not affect lifespan under AL. Lifespan extension under modified sDR regimen is diminished by egl-9 mutation. egl-9 mutation significantly suppresses the lifespan extension by a strong loss-of-function allele of eat-2. Lifespan extension by deletion mutants of rsks-1 is fully suppressed by egl-9 mutation [19461873]. | Worm | — | — | — |
| fem-3 mutation | fem-3(e1996) mutants do not produce sperm or self-progeny, therefore develop as females, but have a normal lifespan (See also ref 10) [8247153]. | Worm | — | — | — |
| fog-2 mutation | fog-2(q71) allele has no effect on lifespan [10747056]. fog-2 mutant display hermaphrodite specific germ line feminization [11076749]. | Worm | — | — | — |
| ctbp-1 mutation | Genetic inactivation of ctbp-1 results in lifespan extension dependent on daf-16, but independent of sir-2.1. RNAi of lips-7(C09E8.2) suppresses lifespan extension by ctbp-1 inactivation [19164523]. | Worm | — | — | — |
| glp-1 mutation | glp-1(qu158) mutations result in defects in germ-line proliferation and extension of lifespan by about 30%, which requires daf-16 [11799246]. glp-1(bn18) mutation increases mean, median, 75th %ile and maximum lifespan by 27-37, 26-33, 24-29 and 35%, respectively [22560223]. glp-1(e2141) mutation increases mean (32%) and maximum (53%) lifespan [18828672]. Two alleles of glp-1 that cause overproliferation of gemrline cells, glp-1(oz112gf) and glp-1(q485), result in a shortened lifespan [11799246]. In glp-1 mutants, Z2 and Z3 generate only a few germ cells, which enter meiosis and differentiate as sperm [3677168]. | Worm | +27 to +37 | +26 to +33 | +35 |
| hcf-1 mutation | hcf-1 inactivation by mutation cause a daf-16-dependent lifespan extension of up to 40% and heightened resistance to specific stimuli [18828672].
HCF-1 forms a complex with DAF-16. hcf-1 inactivation by mutation cause a daf-16-dependent lifespan extension of up to 40% and heightened resistance to specific stimuli. The hcf-1(ok559) mutation increases mean and maximum lifespan by 10-37 and 29%, while the strong hcf-1(pk924) mutation extends mean and maximum lifespan by 29-31 and 53-88%, respectively. In the absence of hcf-1 there is a greater enrichment of DAF-16 at its target gene promoters and more robust DAF-16-mediated regulation of selective transcriptional targets. hcf-1 mutation extends lifespan of glp-1(e2141) mutants which lack germline cells, [18828672]. | Worm | +10 to +37 | — | +29 to +88 |
| hif-1 mutation | hif-1 mutation does not suppress lifespan extension of bDR or eat-2 mutation [19372390]. hif-1 deletion extends lifespan by 24%. hif-1 mutation extends lifespan under AL, but does not further extend lifespan extension under modified sDR. hif-1 mutation does not further extend rsks-1 lifespan. pha-4 RNAi slightly reduces lifespan in wild-type and hif-1 mutants, but hif-1 mutation extends lifespan of animals treated with control or pha-4 RNAi to a similar level [19461873].
| Worm | — | — | — |
| him-6 RNAi | him-6 mutants have a low brood size, a shortened lifespan, and an increased amount of germ-line apoptosis [16181657]. | Worm | — | — | — |
| hsb-1 mutation | hsb-1(cg116) mutation at 20 degree Celsius extends mean, 75%ile, and maximum lifespan by 57-60%, 52-59%, and 37-69%.
| Worm | +57 to +60 | — | +37 to +69 |
| hsp-12.6 mutation | hsp-12.6 loss-of-function mutation significantly extends lifespan under AL and significantly suppresses intermittent fasting (IF)-induced increase in lifespan, to a similar extend to that of daf-16 mutation. The extent of IF-induced longevity in daf-16 hsp-12.6 double mutant is similar to that of single hsp-12.6 or daf-16 mutants. hsp-12.6 and daf-16 function in same signaling pathway [19079239]. | Worm | — | — | — |
| ire-1 mutation | ire-1 mutation reduces slightly the lifespan under AL, but reduces significantly the lifespan extension by DR. ire-1 mutant has a significantly reduced slope in mean lifespan versus food concentrations relative to wild-type. ire-1 mutation fully suppresses lifespan extension by hif-1 mutation under AL and DR conditions [19461873]. | Worm | — | — | — |
| asg-2 mutation | Knockout mutations in asg-2 result in developmental arrest and increased lifespan [11410594]. | Worm | — | — | — |
| kri-1 mutation | kri-1(ok1251) mutation does not shorten the lifespan significantly [22560223]. | Worm | — | — | — |
| cup-4 mutation | Lifespan of cup-4 mutants increases only moderately by sDR [19783783]. | Worm | — | — | — |
| daf-11 mutation | Lifespan of daf-11(m84) mutant is not significant different from wild type [8247153]. | Worm | — | — | — |
| nlp-7 mutation | Lifespan of nlp-7 mutants increases only moderately by sDR [19783783]. | Worm | — | — | — |
| mev-1 mutation | Loss of function in mev-1 shortens lifespan to 66% of wild-type (i.e. by 34%) and accelerates accumulation of aging-associated biomarkers such as protein carboynls and fluorescent materials. mev-1 mutants are hypersensitive to raised oxygen concentrations and their lifespan decreases dramatically as oxygen concentrations increase [9716135]. Mutation of mev-1 results in paraquat sensitivity, slow grows, and low fecundity. mev-1 mutants have a 50% reduction in superoxide dismutase activt relatively to wild-type [2233820]. | Worm | — | — | — |
| unc-2 mutation | Loss of function in unc-2 has no effect on lifespan [9789046].
unc-2 mutant is uncoordinated [4366476] and its rate of pharyngeal pumping is reduced [8325482]. | Worm | — | — | — |
GenAge
GenDR
