| mboa-1 RNAi | RNA interference of mboa-1 decreases median lifespan by 16% in wild type animals, 28% in a daf-2 background and 12% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -16 | — |
| C14A4.9 RNAi | RNA interference of C14A4.9 decreases median lifespan by 14% in wild type animals and 41% in daf-2 mutants [18006689]. | Worm | — | -14 | — |
| skn-1 mutation | skn-1 mutation does not alter lifespan under AL, but cancels out the lifespan extension effect of lDR or food variation at all. Response to lDR in skn-1 mutant is restored by ectopic expression of skn-1 in ASI neurons and gut. Ectopic expression of skn-1b in ASI neurons rescued lDR longevity defects of skn-1. lDR worms exhibit elevated respiration, which is absent in skn-1 mutants. skn-1 is necessary for increased respiration and the increase in respiration is necessary for lDR longevity effect, because two different inhibitors of mitochondrial electron transport chain complex III, myxothiazol and antimycin, suppress lDR longevity without shortening lifespan under AL. IF significantly extends lifespan of skn-1 mutants [19079239]. sDR extends lifespan of a skn-1 loss-of-function mutant (which displays a premature stop codon in all three isoforms) and wild-type to a similar extent [19239417]. skn-1(zu67) mutation decreases mean, median, and maximum lifespan by 11-23, 13-28 and 12-23%, respectively, and totally cancels out lifespan extension by ragc-1 RNAi [22560223]. | Worm | -11 to -23 | -13 to -28 | -12 to -23 |
| C26B0.3 RNAi | RNA interference of C26B0.3 decreases median lifespan by 12% in wild type animals, 68% in a daf-2 background and 17% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -12 | — |
| C29F9.2 RNAi | RNA interference of C29F9.2 decreases median lifespan by 12% in wild type animals and 36% in daf-2 mutants [18006689]. | Worm | — | -12 | — |
| cua-1 RNAi | RNA interference of cua-1 decreases median lifespan by 12% in wild type animals and 30% in daf-2 mutants. | Worm | — | -12 | — |
| C11H1.3 RNAi | RNA interference of C11H1.3 decreases median lifespan by 10% in wild type animals, 14% in a daf-2 background and 41% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -10 | — |
| mdh-1 RNAi | RNAi against mdh-1 decreases median lifespan by 10% in wild type animals and by 16% in daf-2 mutants. mdh-1 RNAi started after the animal reached the late L4 stage increases mean and maximum lifespan by 4-27% and 9% [22103665]. | Worm | +4 to +27 | -10 | +9 |
| ain-1 RNAi | RNA interference of ain-1 decreases median lifespan by 10% in wild type animals, 20% in a daf-2 background and 44% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -10 | — |
| elo-2 RNAi | elo-1 RNAi in the adulthood extends lifespan by 8% [21386131]. | Worm | — | +8 | — |
| ubh-4 RNAi | RNAi of ubh-4 starting at L1 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. | Worm | +3 | +8 | — |
| rnf-5 RNAi | RNAi of rnf-5 starting at L1 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. | Worm | +3 | +8 | — |
| C18E9.4 RNAi | RNAi of C18E9.4 starting at L1 results in mean and median lifespan extension by about 4 and 8% [15998808]. | Worm | +4 | +8 | — |
| inx-14 RNAi | RNAi of inx-14 starting at L1 increases mean, 25%ile and median lifespan by 6, 8 and 14% [15998808]. | Worm | +6 | +8 | — |
| F35D2.3 RNAi | RNAi of F35D2.3 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. | Worm | +3 | +8 | — |
| F40F8.5 RNAi | RNAi of F40F8.5 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. | Worm | +3 | +8 | — |
| drr-1 RNAi | RNAi of drr-1 starting at L1 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. drr-1 RNAi significantly extends mean lifespan of wild-type by 37 - 44%, of daf-16 mutants by 18%, and of daf-2 mutants by 14%, but does not extend significantly the lifespan of eat-2 mutants. drr-1 RNAi does not affect pumping, but similar to DR reduces and delays reproduction as well as causes a slender appearance. drr-1 mRNA is 2-fold downregulated in response to DR [16103914]. | Worm | +3 to +44 | +8 | — |
| spt-4 RNAi | RNAi of spt-4 starting at L1 extends mean, 75%ile and median lifespan by 4, 8 and 8% [15998808]. | Worm | +4 | +8 | — |
| mecr-1 RNAi | RNAi of mecr-1 extends mean, median and 25%ile lifespan by 6, 8 and 8% [15998808]. | Worm | +6 | +8 | — |
| crtc-1 RNAi | RNAi of crtc-1 extended median lifespan by up to 53% [21331044]. | Worm | — | +53 | — |
| vps-37 RNAi | RNA interference of vps-37 decreases median lifespan by 44% in wild-type animals, 47% in a daf-2 background and 33% in daf-2/daf-16 double mutants [18006689]. | Worm | — | +44 | — |
| eif-1 RNAi | RNA interference against eif-1 in the adulthood extends mean lifespan by 25% [17411345]. eif-1 RNAi only during the adulthood increases mean, median and 75th %ile lifespan by 23-35, 38 and 22-40%, respectively [22560223]. | Worm | +23 to +35 | +38 | — |
| ifg-1 RNAi | RNA interference against ifg-1 in the adulthood results in a 55% mean lifespan extension [17411345]. ifg-1 RNAi only in the adulthood increases mean, median and 75th %ile lifespan by 49, 33, and 35%, respectively [22560223]. RNAi knockdown of ifg-1 continuously at 25.5 degree Celsius extends mean and maximum lifespan by 31 and 11%, while knockdown restricted to the adulthood extends mean and maximum lifespan by 45 and 28% [16720740]. | Worm | +31 to +55 | +33 | +11 to +28 |
| glp-1 mutation | glp-1(qu158) mutations result in defects in germ-line proliferation and extension of lifespan by about 30%, which requires daf-16 [11799246]. glp-1(bn18) mutation increases mean, median, 75th %ile and maximum lifespan by 27-37, 26-33, 24-29 and 35%, respectively [22560223]. glp-1(e2141) mutation increases mean (32%) and maximum (53%) lifespan [18828672]. Two alleles of glp-1 that cause overproliferation of gemrline cells, glp-1(oz112gf) and glp-1(q485), result in a shortened lifespan [11799246]. In glp-1 mutants, Z2 and Z3 generate only a few germ cells, which enter meiosis and differentiate as sperm [3677168]. | Worm | +27 to +37 | +26 to +33 | +35 |
| raga-1 RNAi | raga-1 RNAi only during adulthood increases mean, median, 75th %ile and maximum lifespan by 9-42, 26-28, 16-52 and 35%, respectively, but failed so in skn-1 or daf-16 mutant (with and without FUdR). Lifespan of the skn-1;daf-16 mutant was unaffected by raga-1 RNAi. Knockdown of raga-1 dramatically increases stress tolerance in an skn-1 but not daf-16-dependent manner [22560223]. | Worm | +9 to +42 | +26 to +28 | +35 |
GenAge
GenDR
