| YLR460C deletion | Deletion of YLR460C decreases replicative lifespan by 30% in the alpha strain [19030232]. | Worm | -30 | — | — |
| mir-14 mutation | Mutating mir-14 decreases lifespan in both sexes. mir-14 reduces the mean and maximum lifespan of females by 55 and 36%, respectively, while those of males is reduced by 29 and 21%, respectively [12725740]. | Worm | -29 to -55 | — | -21 to -29 |
| dcp-66 RNAi | dcp-66 RNAi shortens the mean lifespan by 29% and suppresses lifespan extension by isp-1 mutation, but does not significantly affect lifespan extension neither by eat-2 nor daf-2 mutation [22829775]. | Worm | -29 | — | — |
| phi-50 RNAi | RNA interference of phi-50 decreases mean lifespan by 29% and suppresses lifespan extension by isp-1 and eat-2 mutation but does not significantly affect lifespan extension by daf-2 [22829775]. | Worm | -29 | — | — |
| rpt-1 RNAi | rpt-1 RNAi in the adulthood decreases the mean and maximum lifespan by 28 and 50%, respectively [23144747]. | Worm | -28.4 | — | -50.0 |
| pat-3 RNAi | pat-3 RNAi in the adulthood decreases mean and maximum lifespan by 28% and 50%, respectively [23144747]. | Worm | -28.1 | — | -50.0 |
| gei-4 RNAi | gei-4 RNAi in the adulthood reduces mean and maximum lifespan by 27 and 38% [23144747]. | Worm | -27.0 | — | -38.0 |
| daf-16 RNAi | Knockdown of daf-16 decreases mean and maximum lifespan by 50% and 54%, respectively [22509016].
RNAi against daf-16 decreases lifespan of wild-type, daf-2 or glp-1 mutants [22509016; 16530050]. daf-16 RNAi completely blocks lifespan extension by daf-2 mutation, but only partially by bDR. daf-16 RNAi attenuates protection against oxidative stress by bDR. Knockdown of daf-16 decreases mean and maximum lifespan by 50% and 54%, respectively [22509016]. daf-16 RNAi decreases mean lifespan by 27% [18828672].
| Worm | -27 to 50 | — | -54 |
| Sex | Mating reduces average and maximum male lifespan by 27% and 18%, respectively, while the mean lifespan of mated hermaphrodites is not significantly different from unmated ones (however maximum lifespan of unmated hermaphrodites was extend by 24%). Even a short mating interval significantly reduces male lifespan. Males which mate only during the first 30 h of their lifespan have a similar short lifespan than those males which were kept with hermaphrodites their entire life. Males mated with an 3-fold excess of hermaphrodites have a decreased mean and maximum lifespan by 38 and 24%, respectively. The physical act of mating in itself does not reduce lifespan [1448167]. | Worm | -27 to -38 | — | -18 to -24 |
| mir-61 mir-250(nDf59) mutation | mir-61 mir-250(nDf59) mutation decreases the mean lifespan by 25% [22482727]. | Worm | -25 | — | — |
| nekl-2 RNAi | RNA intereference of nekl-2 decreases lifespan by 24% and suppresses lifespan extension by eat-2 mutation [22829775]. | Worm | -24 | — | — |
| dpy-27 RNAi | dpy-27 RNAi in the adulthood shortens mean and maximum lifespan by 24 and 25%, respectively [23144747]. | Worm | -23.5 | — | -25.0 |
| ncbp-2 RNAi | RNAi against ncbp-2 decreases mean and maximum lifespan by 23-25% and 7%, respectively [18059442]. | Worm | -23 to -25 | — | -7 |
| cdtl-7 RNAi | RNAi against cdtl-7 starting in the adulthood decreases mean and maximum lifespan by 22 and 25%, respectively [23144747]. | Worm | -22.2 | — | -25.0 |
| ctdl-7 RNAi | RNAi against cdtl-7 starting in the adulthood decreases the mean lifespan by 22.2% [New longevity regulators]. | Worm | -22.2 | — | — |
| rpt-2 RNAi | Knockdown of rpt-2 via RNAi started after the animal reached the late L4 stage decreases mean lifespan by 20-32% [22103665]. | Worm | -20 to -32 | — | — |
| sptf-3 RNAi | RNAi against sptf-3 decreases mean and maximum lifespan by 20 - 28% and 28%, respectively [18059442]. sptf-3 RNAi in the adulthood decreases the mean and maximum lifespan by 23 and 37% [23144747]. | Worm | -20 to -28 | — | -28 to -37 |
| amt-2 RNAi | RNA interference of amt-2 increases mean lifespan by 20% [17608836]. | Worm | -20 | — | — |
| mir-58 mutation | mir-58(n4640) mutation decreases the mean lifespan by 20% [22482727]. | Worm | -20 | — | — |
| mir-80 mir-227(nDf53); mir-81-82(nDf54) | mir-80 mir-227(nDf53); mir-81-82(nDf54) mutation decreases the mean lifespan by 20% [22482727]. | Worm | -20 | — | — |
| rpn-11 RNAi | rpn-11 RNAi in the adulthood decreases mean and maximum lifespan by 19 and 25%, respectively [23144747]. | Worm | -19.3 | — | -25.0 |
| Y47D3A.29 RNAi | RNAi against Y47D3A.29 decreases mean and maximum lifespan by 19-26% and 34% [18059442]. | Worm | -19-26 | — | -34 |
| daf-5 mutation | daf-5(e1386) mutation reduces mean lifespan by 19% and maximum lifespan by 21% [17900898]. | Worm | -19 | — | -21 |
| pcf-11 RNAi | pcf-11 RNAi in the adulthood decreases mean and maximum lifespan by 19 and 25% [23144747]. | Worm | -18.9 | — | -25.0 |
| daf-16 mutation | daf-16(m26) mutation slightly, insignificantly decreases lifespan, but completely suppresses lifespan extension of daf-2(e1370) adults [8247153]. daf-16 is required for lifespan extension by mutation of daf-2 or age-1 [8247153]. Mutations in daf-16 suppressed life-extension caused by mutations in daf-2 [8247153]. Loss of function alleles of daf-16 shorten lifespan, but some alleles have lifespan equal to wild-type [8247153]. daf-16 mutation significantly reduces lifespan under AL (-20%), but does not prevent lifespan extension by sDR. In another experiment daf-16 mutation totally suppresses lifespan extension by sDR [16720740]. sDR does not stimulate DAF-16 translocation to the nucleus, but daf-16 mutation cancelled out the ability of sDR to extend lifespan and to delay the decline in locomotor activity [17900900]. DR by bacterial dilution extends lifespan of daf-16 mutants [17538612]. daf-16 mutation decreases lifespan under AL, but fails to prevent bDR to further extend lifespan [18331616]. IF-induced lifespan-extension by either 24h/48h/72h per 4 days is significantly diminished in null mutants of daf-16. All these regimens extend lifespan of daf-16 to a lesser extent than wild-type. daf-16 partially mediates IF-induced longevity [19079239]. Glucose or glycerol does not shorten lifespan of daf-16 mutants [19883616]. daf-16 mutation cancels out the lifespan extension effect of sDR and PD, regardless of the concentration of bacteria or peptones. bDR significantly extends lifespan of daf-16 mutants, but to a lesser extent than that of wild-type. eat-2 mutation extends the lifespan of daf-16 mutants to the same extent than that of wild-type. Resveratrol extends lifespan of daf-16 mutants [19239417]. daf-16 RNAi completely blocks lifespan extension by daf-2 mutation, but only partially by bDR. daf-16 RNAi attenuates protection against oxidative stress by bDR. daf-16 expression is induced by bDR [19924292]. Knockdown of daf-16 decreases mean and maximum lifespan by 50% and 54%, respectively [22509016]. DAF-16 reduces expression of rsks-1 and daf-15 [15253933; 22560223]. daf-16(mu86) mutation decreases mean (44%) and maximum (18%) lifespan [15905404]. daf-16(mgDf47) decreases mean (18-37%) and maximum (29%) lifespan [18828672]. daf-16 mutants are dauer defective [7219552] and completely suppress all the phenotypes of daf-2 and age-1 mutations, including lifespan extension, dauer arrest, reduced fertility, and viability defects [8247153; 7789761; 9504918; 7789761]. Mutations in daf-16 also suppress lifespan extension of animals that have a germ line ablation [10360574]. Sex-specific lifespan potential requires daf-16 [10747056].
daf-16 mutation suppresses enhanced UV resistance as well as increase longevity of daf-2, daf-23, spe-26, and clk-1 mutants. Mutation in daf-16 does not alter the reduced fertility in spe-26. daf-16 mutants are more fertile than wild-type [8807294]. | Worm | -18 to -37 | — | -29 |
GenAge
GenDR
