| sptf-3 RNAi | RNAi against sptf-3 decreases mean and maximum lifespan by 20 - 28% and 28%, respectively [18059442]. sptf-3 RNAi in the adulthood decreases the mean and maximum lifespan by 23 and 37% [23144747]. | Worm | -20 to -28 | — | -28 to -37 |
| cdtl-7 RNAi | RNAi against cdtl-7 starting in the adulthood decreases mean and maximum lifespan by 22 and 25%, respectively [23144747]. | Worm | -22.2 | — | -25.0 |
| rpn-11 RNAi | rpn-11 RNAi in the adulthood decreases mean and maximum lifespan by 19 and 25%, respectively [23144747]. | Worm | -19.3 | — | -25.0 |
| pcf-11 RNAi | pcf-11 RNAi in the adulthood decreases mean and maximum lifespan by 19 and 25% [23144747]. | Worm | -18.9 | — | -25.0 |
| dpy-27 RNAi | dpy-27 RNAi in the adulthood shortens mean and maximum lifespan by 24 and 25%, respectively [23144747]. | Worm | -23.5 | — | -25.0 |
| let-4 RNAi | RNA intereference of let-4 extends mean and 75%ile lifespan by 4%, but reduces maximum lifespan by 25% [22768380]. | Worm | +4 | — | -25 |
| mir-238 mutation | Mutating mir-238 decreases mean and maximum lifespan by 18 and 24% [21129974]. mir-238(n4112) mutation decreases mean lifespan by 20% [22482727]. | Worm | -17.6 to -20 | — | -24 |
| mir-14 mutation | Mutating mir-14 decreases lifespan in both sexes. mir-14 reduces the mean and maximum lifespan of females by 55 and 36%, respectively, while those of males is reduced by 29 and 21%, respectively [12725740]. | Worm | -29 to -55 | — | -21 to -29 |
| daf-5 mutation | daf-5(e1386) mutation reduces mean lifespan by 19% and maximum lifespan by 21% [17900898]. | Worm | -19 | — | -21 |
| tbp-1 RNAi | RNAi against tbp-1 decreases mean and maximum lifespan by 15-27% and 21%, respectively [18059442]. | Worm | -15-27 | — | -21 |
| Sex | Mating reduces average and maximum male lifespan by 27% and 18%, respectively, while the mean lifespan of mated hermaphrodites is not significantly different from unmated ones (however maximum lifespan of unmated hermaphrodites was extend by 24%). Even a short mating interval significantly reduces male lifespan. Males which mate only during the first 30 h of their lifespan have a similar short lifespan than those males which were kept with hermaphrodites their entire life. Males mated with an 3-fold excess of hermaphrodites have a decreased mean and maximum lifespan by 38 and 24%, respectively. The physical act of mating in itself does not reduce lifespan [1448167]. | Worm | -27 to -38 | — | -18 to -24 |
| aak-2 mutation | aak-2(ok524) knockout mutants have a 12% and 18% shorter mean and maximum lifespan, respectively as well as faster age-dependent accumulation of a lipofuscin-like fluorescent pigment in the intestine [15574588]. aak-2 mutation suppresses lifespan extension and delay of the decline in locomotor activity resulting from sDR [17900900]. aak-2 mutation cancels out the lifespan extension effect of sDR and PD, regardless of the concentration of bacteria or peptones. bDR significantly extends lifespan of aak-2 mutants, but to lesser extent than that of wild-type. eat-2 mutation extends the lifespan of aak-2 mutants to the same extent than that of wild-type. Resveratrol does not increase lifespan of aak-2 mutants [19239417]. daf-2(m577);aak-2(ok524) double mutant has a lifespan that is indistinguishable from those of aak-2(ok524) single mutant [15574588]. | Worm | -12 | — | -18 |
| bar-1 mutation | BAR-1 may play a role in regulating daf-16 during dauer formation, particularly in conditions of oxidative stress as it directly interaction with DAF-16 and loss of bar-1 reduces activity of DAF-16 in dauer formation and lifespan. Deletion of bar-1 reduces mean (44%) and maximal (18%) lifespan, which is to a similar degree as seen to daf-16 mutants [15905404]. | Worm | -44 | — | -18 |
| mir-239 overexpression | Overexpressing mir-239 decreases mean and maximum lifespan by 13 and 17 - 33%, respectively [21129974]. | Worm | -13 | — | -17 to -33 |
| alg-1 RNAi | Adult-specific knockdown of the C. elegans argonaute-like gene 1 *alg-1* results in shortened lifespan with a reduction in the mean and maximum lifespan by 9 - 16% and 14%, respectively [21810936]. | Worm | -9.6 to -16.1 | — | -13.7 |
| mir-246 mutation | Mutating mir-246 decreases mean and maximum lifespan by 12% [21129974]. | Worm | -11.7 | — | -12.0 |
| skn-1 mutation | skn-1 mutation does not alter lifespan under AL, but cancels out the lifespan extension effect of lDR or food variation at all. Response to lDR in skn-1 mutant is restored by ectopic expression of skn-1 in ASI neurons and gut. Ectopic expression of skn-1b in ASI neurons rescued lDR longevity defects of skn-1. lDR worms exhibit elevated respiration, which is absent in skn-1 mutants. skn-1 is necessary for increased respiration and the increase in respiration is necessary for lDR longevity effect, because two different inhibitors of mitochondrial electron transport chain complex III, myxothiazol and antimycin, suppress lDR longevity without shortening lifespan under AL. IF significantly extends lifespan of skn-1 mutants [19079239]. sDR extends lifespan of a skn-1 loss-of-function mutant (which displays a premature stop codon in all three isoforms) and wild-type to a similar extent [19239417]. skn-1(zu67) mutation decreases mean, median, and maximum lifespan by 11-23, 13-28 and 12-23%, respectively, and totally cancels out lifespan extension by ragc-1 RNAi [22560223]. | Worm | -11 to -23 | -13 to -28 | -12 to -23 |
| old-1 overexpression | Overexpression of old-1 in transgenic animals increases mean and maximum lifespan by 40-100% (average 65%) and 97%, respectively. old-1 overexpression of increases stress resistance (to heat by 20% and ultraviolet irradiation by 33%) without altering development or fertility. Effects of old-1 on lifespan and stress resistance is under regulation of daf-16 [9768365]. | Worm | +40 to +100 | — | +97 |
| aco-2 RNAi | Knockdown of aco-2 via RNAi started after the animal reaches the L4 stage extends mean and maximum lifespan by 9-14% and 9%, respectively [22103665]. | Worm | +9 to +14 | — | +9 |
| mdh-1 RNAi | RNAi against mdh-1 decreases median lifespan by 10% in wild type animals and by 16% in daf-2 mutants. mdh-1 RNAi started after the animal reached the late L4 stage increases mean and maximum lifespan by 4-27% and 9% [22103665]. | Worm | +4 to +27 | -10 | +9 |
| chn-1 RNAi | chn-1 RNAi in the adulthood extends mean and maximum lifespan by 7 and 9%, respectively [23144747]. | Worm | +7.1 | — | +8.7 |
| nhr-23 RNAi | nhr-23 RNAi in the adulthood extends mean and maximum lifespan by 5 and 9%, respectively [23144747]. | Worm | +4.9 | — | +8.7 |
| emb-27 RNAi | emb-27 RNAi in the adulthood extends mean and maximum lifespan by 11 and 9%, respectively [23144747]. | Worm | +10.5 | — | +8.7 |
| lin-5 RNAi | lin-5 RNAi in the adulthood extends mean and maximum lifespan by 16 and 9% [23144747]. | Worm | +16.4 | — | +8.7 |
| mel-28 RNAi | mel-28 RNAi in the adulthood extends mean and maximum lifespan by 7 and 9%, respectively [23144747]. | Worm | +6.5 | — | +8.7 |
GenAge
GenDR
