| yata mutation | yata mutation shortens the maximum lifespan by 68% and results in progressive deterioration of the nervous tissues and aberrant accumulation of Sec23 [19209226]. | Fly | — | — | -68 |
| CG3776 underexpression | Underexpression of CG3776 (alias Jhebp29) reduces the mean lifespan, where the reduction in males is slightly higher. The lifespan of females and male flies underexpressed CG3776 is reduced by 31.6% and 38.8%, respectively when compared with Oregon R flies [18275960]..
| Fly | -31.6 to -38.8 | — | — |
| l(3)neo18 RNAi | Under rich nutritional conditions lifespan of l(3)neo18 (alias CG9762) RNAi knockout animals is indistinguishable from wild-type, while upon DR, lifespan extension is diminished in males and females [19804760]. | Fly | — | — | — |
| Dominant-negative S6k | Ubiquitous overexpression of a dominant-negative form of S6k (alias dS6K) increases mean lifespan by 22%. Overexpression of a dominant-negative form of S6k protects mutants from deleterious effects of rich food, as if mimicking the effect of DR [15186745]. | Fly | +22 | — | — |
| rut mutation | Two rutabaga mutants, rut1 and rut2080, have significantly shortened lifespans [17369827]. | Fly | — | — | — |
| Trx-2 mutation | Trx-2 mutants have a 25% reduction in maximum lifespan and exhibit lower tolerance to oxidative stress while animals carrying multiple copies of Trx-2 exhibit higher tolerance [17567437]. | Fly | — | — | -25 |
| miR-277 inhibition | Transgenic inhibition of miR-277 with a miRNA sponge construct shortens lifespan [23669073]. | Fly | — | — | — |
| Edem1 mutation | The mean lifespan of Edem1 mutants of both male and female is increased by more than 30% [19302370]. | Fly | +30 | — | — |
| ovo mutation | The dominant ovoD1 allele extends female lifespan by approximately 50%. It does not synergize or prevent life-extension caused by chico [10617470; 11292874].
ovoD1 mutants are sterile [Mevel-Ninio et al. 1991]. | Fly | +50 | — | — |
| Surf1 knockdown | Surf1 knockdown results in larval lethality. However, knockdown in the central nervous system (CNS) not only bypasses the larval lethality but it results in an increase in maximum lifespan of about 20-30% [16172499]. | Fly | — | — | +20 to +30 |
| sun mutation | sun mutations increases lifespan and resistance to oxidative stress [15133470] | Fly | — | — | — |
| Sod1 knockdown | Sod1 knockdown by RNAi blunts the lifespan extension by a high sugar-low protein diet, but not a low-calorie diet [22672579]. | Fly | — | — | — |
| Sod mutation | Sod mutant flies display infertility and a reduction in lifespan [2539600]. | Fly | — | — | — |
| Sod knockout | Sod knockout blunts the lifespan extension by a high sugar-low protein diet, but not a low-calorie diet [22672579]. | Fly | — | — | — |
| sgg transposition | Several insertions of P-based vectors in the structural part of sgg are associated with alterations of male and female lifespan [22661237]. | Fly | — | — | — |
| SdhB mutation | SdhB mutants are hypersensitive to oxygen and displays signs of premature aging, including a 66% decrease in mean lifespan and a 17% decrease in maximum lifespan [17056719]. | Fly | -66 | — | -17 |
| CG5389 RNAi | RNAi of complex V subunit CG5389 results in increased mean longevity under standard laboratory food conditions (3% yeast) in males. RNAi started from the development results in a mild lifespan increase in both sexes (3-11% in females and 3-8% in males). Post-developmental RNAi and silencing limited to neurons has variable effects with reduction in lifespan of up to 9% [19747824]. Under rich media conditions CG5389 knockdown throughout development and adulthood increases mean lifespan by 26% and abolished the lifespan extension by DR (started in the adulthood) in males. Suppression of CG5389 only during the adulthood either via RNAi by tub-GS or via oligomycin (a specific inhibitor of complex V) feeding prevents an increase in longevity under DR (started in the adulthood) in males [19968629]. | Fly | -9 to +26 | — | — |
| CG18809 RNAi | RNAi of CG18809 results in a 7-19% increase in mean lifespan of females, while neural RNAi results in an increased mean lifespan of up to 12% in females. For males the results are variable [19747824]. | Fly | +7 to +19 | — | — |
| CG17856 RNAi | RNAi of CG17856 results in an increase in mean lifespan of 13-18% in females. In the case of males and post-developmental experiments the results are variable [19747824]. | Fly | +13 to +18 | — | — |
| CG9172 RNAi | RNAi against CG9172 increases mean lifespan in females by up to 4-12% when applied in both development and adulthood, and up to 46% when applied in adult neurons only. For males the effect is variable [19747824]. | Fly | +4 to +46 | — | — |
| Sod2 RNAi | RNA interference of Sod2 results in increased oxidative stress and early-onset mortality in young adults [12456885]. | Fly | — | — | — |
| Mlp84B RNAi | RNA interference of Mlp84B specifically in the heart results in bradycardia and heart rythm abnormalities as well as a shorter mean lifespan in males but not in females [18083727]. | Fly | — | — | — |
| DJ-1alpha RNAi | RNA interference of DJ-1alpha shortens maximum lifespan by 13% and results in increased sensitivity to oxidative stress and motor impairments [17651920]. | Fly | — | — | -13 |
| bsk RNAi | RNA interference of bsk in intestinal stem cells, results in short lived mutants with impaired intestinal homeostasis and tissue regeneration. The mean lifespan of males is 16.4% lower and those of female is reduced by 10.2% [20976250]. | Fly | -10.2 to -16.4 | — | — |
| Akt1 RNAi | RNA interference of Akt1 in intestinal stem cells, results in impaired regeneration of the intestinal epithelium and a short lifespan. In males and females on mean lifespan is 11.4% and 7.4% lower [20976250]. | Fly | -11.4 to -7.4 | — | — |
GenAge
GenDR
