| unc-76 mutation | unc-76(e911) allele extends male lifespan by about 50%, but has no effect on hermaphrodite lifespan [10747056].
unc-76 mutants are uncoordinated [4366476]. | Worm | +50 | — | — |
| unc-51 mutation | unc-51(e369) mutation reduces mean but extends maximum lifespan. unc-51(e369) mutation reduces lifespan of eat-2(ad1116) mutants to that of wild-type [18219227]. | Worm | — | — | — |
| unc-46 mutation | unc-46(e177) allele has no significant effect on lifespan [9789046].
unc-46 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-35 mutation | unc-35(e259) has no effect on male or hermaphrodite lifespan [10747056].
unc-35 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-32 mutation | unc-32 mutation extends male lifespan by about 170%, but has no effect on hermaphrodite lifespan [10747056].
unc-31 mutants are uncoordinated [4366476]. | Worm | +170 | — | — |
| Coq7 overexpression | Transgenic overexpression of mouse Coq7 reverts the extended lifespan of clk-1 mutants [11511092]. | Worm | — | — | — |
| SNCA overexpression | Transgenic lines overexpressing either human wild-type or mutant (A53T) forms of the SNCA (alpha-synclein) gene under a pan-neuronal promoter live on average about 25% longer, even in weak (m577) and strong (e1370) daf-2 mutant backgrounds, and exhibited decreased pharyngeal pumping and egg-laying. Wild-type SNCA crossed into eat-2(ad1113) does not significantly effect lifespan compared to that of the background strain. Pumping rate in wild-type SCNA and A53T SCNA overexpression mutants were less than control already at day 1 of adulthood. The attenuation of lifespan exptesion by SNCA overexpression by growing on thick bacterial lawns, suggests that DR may explain some fo the effects on lifespan. SCNA overexpression increases average lifespan by 21.3% (wild-type) and 16.3% (A53T) [16782295]. | Worm | +26 to +34 | — | +19 to +31 |
| unc-80 mutation | The unc-80(e1069) allele has no significant effect on lifespan [9789046].
unc-80 mutant displays irregular movement [4366476] | Worm | — | — | — |
| unc-79 mutation | The unc-79(e1068) allele has no significant effect on lifespan [9789046].
unc-78 mutants display irregular movement [4366476]. | Worm | — | — | — |
| unc-47 mutation | The unc-47(e367) allele has no significant effect on lifespan [9789046].
unc-47 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| Activating let-60 mutation | The let-60(n1046gf) activating mutation greatly reduces lifespan of wild-type, weakly suppresses constitutive dauer diapause in daf-2 and age-1 mutants and extends lifespan induced by mutation of daf-2 [16164423]. | Worm | — | — | — |
| fog-1 mutation | The fog-1(q180) allele has no effect on lifespan [11799246]. fog-1 mutants are sterile and make oocytes but not sperm [2341035]. | Worm | — | — | — |
| eat-7 mutation | The eat-7(ad450) allele decreases lifespan by 35% [9789046] exhibits defects in pharyngeal feeding behavior [8462849]. | Worm | -35 | — | — |
| eat-5 mutation | The eat-5(ad464) allele has no significant effect on lifespan [9789046], although it displays defects in pharyngeal feeding behaviour [8462849]. | Worm | — | — | — |
| eat-3 mutation | The eat-3(ad426) allele extends lifespan by 10%. Lifespan extension is proposed to be similar to DR [9789046]. eat-1 mutants have defects in haryngeal feeding behavior [8462849]. | Worm | +10 | — | — |
| eat-13 mutation | The eat-13(ad522) allele extends lifespan by 30%. Extension of lifespan is proposed to be similar to DR [9789046]. eat-1 mutants have defects in pharyngeal feeding behavior [8462849]. | Worm | +30 | — | — |
| eat-10 mutation | The eat-10(ad606) allele exhibits no significant extension of lifespan [9789046], but displays defects in pharyngeal feeding behaviour [8462849]. | Worm | — | — | — |
| ced-3 mutation | The ced-3(n1286) allele has no effect on lifespan, although the transgenic animals are defective in apoptosis [12136014]. | Worm | — | — | — |
| tdp-1 mutation | tdp-1(ok803) mutation increases mean and maximum lifespan at 20 degree Celsius but not at 25 degree Celsius. tdp-1(ok803) reduce the lifespan of daf-2(e1370) mutants, but does not does not reduces the lifespan of daf-16(mu86) mutants [Vaccaro et al. 2012]. | Worm | — | — | — |
| HG25 mutation | Strain HG25 has a lifespan that is 20% longer than wild-type [10708258].
HG25 mutant strain is heat shock resistant [10708258]. | Worm | +20 | — | — |
| HG246 mutation | Strain HG246 has a lifespan that is 30% longer than wild-type [10708258].
mutant HG246 strain is heat shock resistant, exhibit lower fertility, and males are slightly defective for mating [10708258]. | Worm | +30 | — | — |
| spe-26 mutation | spe-26 mutation in both hermaphrodites and mated males renders them defective in spermatogenesis and increases mean lifespan by about 65%. In hermaprodites spe-26(hc138ts) mutation increases mean and maximum lifespan by 46 and 29%, respectively. Mating does not reduce lifespan in male with spe-26 mutation. Animals with a different spe-26 allele, it118ts, have a similar increase in mean lifespan both in mated males and mated hermaphrodites. Mating even increases spe-26 mutant male lifespan, although the increase is slight (16% increase in mean and 13% increase in maximum lifspan. While compared to wild-type mated spe-26 males have an increase in mean and maximum lifespan of 81 and 63%, respectively, in comparison to wild-type [1448167]. spe-26 loss of function mutation extends lifespan [8807294]. | Worm | +46 to +81 | — | +29 to +63 |
| slcf-1 mutation | slcf-1 mutation increases average lifespan by 40%. DR (by dilution of bacteria on solid medium or by bacterial deprivation) failes to extend slcf-1 mutant's long lifespan and lifespan is even reduced by lowering bacteria concentration (i.e. higher strength of DR) [21040400]. | Worm | +40 | — | — |
| Overexpression of constitutive nuclear SKN-1 | skn-1 transgenes that overexpress a constitutive nuclear form of SKN-1 in the intestine extend the mean lifespan by 5-21%, independently of DAF-16 [18358814]. | Worm | +5 to +21 | — | — |
| skn-1 mutation | skn-1 mutation does not alter lifespan under AL, but cancels out the lifespan extension effect of lDR or food variation at all. Response to lDR in skn-1 mutant is restored by ectopic expression of skn-1 in ASI neurons and gut. Ectopic expression of skn-1b in ASI neurons rescued lDR longevity defects of skn-1. lDR worms exhibit elevated respiration, which is absent in skn-1 mutants. skn-1 is necessary for increased respiration and the increase in respiration is necessary for lDR longevity effect, because two different inhibitors of mitochondrial electron transport chain complex III, myxothiazol and antimycin, suppress lDR longevity without shortening lifespan under AL. IF significantly extends lifespan of skn-1 mutants [19079239]. sDR extends lifespan of a skn-1 loss-of-function mutant (which displays a premature stop codon in all three isoforms) and wild-type to a similar extent [19239417]. skn-1(zu67) mutation decreases mean, median, and maximum lifespan by 11-23, 13-28 and 12-23%, respectively, and totally cancels out lifespan extension by ragc-1 RNAi [22560223]. | Worm | -11 to -23 | -13 to -28 | -12 to -23 |
GenAge
GenDR
