| rrf-1 | RNA-dependent RNA polymerase Family | Although rrf-1(pk1417) mutants seem to have elevated DAF-16 activity (as sod-3 transcript level is increased) the mean and maximum lifespan or ability to withstand elevated temperature is not different from wild-type [22574120]. | Nematode |
| — | (-)-epidcatechin | Treatment with (-)-epidcatechin do no extend C. elegans lifespan [20717869]. | Nematode |
| ced-3 | CEll Death abnormality | RNA interference of ced-3 in adulthood results in a 19% increase in mean lifespan [17411345]. The ced-3(n1286) allele has no effect on lifespan, although the transgenic animals are defective in apoptosis [12136014]. | Nematode |
| ctl-1 | CaTaLase 1 | ctl-1 loss of function shortens lifespan to 77% of wild-type animals. ctl-1 mutants accumulate fluorescent material faster than wild-type, indicating accelerated aging [12610632]. ctl-1 mutation prevents lifespan extension by daf-2 or clk-1. Mutation of ctl-1 reudces catalase activty by 50% [10335847].
All these results have been retracted. | Nematode |
| daf-1 | abnormal DAuer Formation | daf-1(mk40) mutation increases mean lifespan by 18-46% and maximum lifespan by 29% [17900898]. The daf-1(m40) allele has no effect on lifespan and fails to prevent lifespan extension by sir-2.1 overexpression, but it results in a temperautre-sensitive, dauer-constitutive phenotype in larvae [11242085]. | Nematode |
| dod-19 | Downstream Of DAF-16 (regulated by DAF-16) | RNA interference of dod-19 extends lifespan by 28%. dod-19 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331]. | Nematode |
| fem-3 | FEMinization of XX and XO animals | fem-3(e1996) mutants do not produce sperm or self-progeny, therefore develop as females, but have a normal lifespan (See also ref 10) [8247153]. | Nematode |
| fog-1 | Feminization Of Germline | The fog-1(q180) allele has no effect on lifespan [11799246]. fog-1 mutants are sterile and make oocytes but not sperm [2341035]. | Nematode |
| fog-2 | Feminization Of Germline 2 | fog-2(q71) allele has no effect on lifespan [10747056]. fog-2 mutant display hermaphrodite specific germ line feminization [11076749]. | Nematode |
| fog-3 | Feminization Of Germline 3 | The fog-3(q470) allele has no effect on lifespan [11799246]. In fog-3 mutant animals cells that would normally become sperm differentiate into oocytes [7713418]. | Nematode |
| ins-22 | INSulin related 22 | RNAi of ins-22 has no effect on lifespan. ins-22 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331]. | Nematode |
| lars-2 | Leucyl Amino-acyl tRNA Synthetase | A mutation that impairs mitochondrial function was associated with a longer lifespan. Mutation of lrs-2/lars-2(mg312) extends lifespan and is associated with impaired mitochondrial function. The recessive allele mg312 of lars-2 extends lifespan by 200% at 20 degree Celsius and 30% at 25 degree Celsius. Lifespan extension by mg312 was not dependent on daf-16(mgDf47). Homozygous lars-2(mg312) worms had multiple pleotropies like lower rates of growth, pumping and defecation as well as remain the size of early L4 worms and are sterile, with an arrested gonad that exhibited no germ-cell differentiation lars-2 is ubiquitously express, with prominent expression in body-wall muscle and neurons, with a mitochondrial subcellular localisation. Mitochondria of lars-2 are noticeably disorganized, swollen and sometimes fused. lars-2 animals have lower ATP content and oxygen consumption [12447374]. | Nematode |
| mec-1 | MEChanosensory abnormality 1 | Loss of function mutations in mec-1 do not effect lifespan [2428682]. mec-1 mutants are touch insenstive, lethargic, and have displacement of some microtubule cells and amphidial neurons as well as defective fasciculation [2428682]. | Nematode |
| sip-1 | Stress Induced Protein 1 | RNAi of sip-1 has no effect on wild-type adult lifespan, but slightly shortens the long lifespan of age-1(hx546) mutant animals [14668486]. | Nematode |
| unc-1 | UNCoordinated 1 | Mutation in unc-1 has no effect on lifespan [9789046]. | Nematode |
| unc-15 | UNCoordinated 15 | Mutation of unc-15 has no effect on lifespan [9789046]. Some alleles of un-15 display severe paralysis [4366476; 2051482]. | Nematode |
| unc-2 | UNCoordinated 2 | Loss of function in unc-2 has no effect on lifespan [9789046].
unc-2 mutant is uncoordinated [4366476] and its rate of pharyngeal pumping is reduced [8325482]. | Nematode |
| unc-24 | UNCordinated 24 | Mutations in unc-24 have no significant effect on lifespan [9789046] and unc-24(e138) fails to extend male lifespan [10747056].
unc-24 mutant is uncoordinated and displays irregular movement [4366476; 8667025]. | Nematode |
| unc-25 | UNCoordinated 25 | Mutations in unc-25 have no effect on lifespan [9789046].
unc-25 mutants are defective for foraging, locomotion, and defecation [8332190] as well as uncoordinated [4366476]. | Nematode |
| unc-29 | UNCoordinated | Mutation in unc-29 has no effect on lifespan [9789046] and fails to extend male lifespan [10747056].
unc-29 mutants are uncoordinated [4366476]. | Nematode |
| unc-30 | UNCoordinated 30 | Mutations in unc-30 have no significant effect on lifespan [9789046].
unc-30 mutants are uncoordinated [4366476]. | Nematode |
| unc-46 | UNCoordinated 46 | unc-46(e177) allele has no significant effect on lifespan [9789046].
unc-46 mutants are uncoordinated [4366476]. | Nematode |
| unc-47 | UNCoordinated 47 | The unc-47(e367) allele has no significant effect on lifespan [9789046].
unc-47 mutants are uncoordinated [4366476]. | Nematode |
| unc-49 | UNCoordinated 49 | The unc-49(e382) allele has no significant effect on lifespan [9789046].
unc-49 mutants are uncoordinated [4366476]. | Nematode |
| unc-54 | UNCoordinated 54 | Mutation in unc-54 has no effect on lifespan [9789046].
unc-54 mutants are paralyzed [4366476]. | Nematode |
