| Mnt | CG13316-PC, isoform C | A dMnt null allele results in flies with larger cells, increased weight, and decreased lifespan [16055719]. | Fruit fly |
| Nlaz | Neural Lazarillo | Absence of Nlaz, which is homologous to ApoD, results in a reduced lifespan in both sexes. Median lifespan is 30.8% and 22.5% lower in females and males, respectively. Maximum lifespan is reduced by 12% and 30% in females and males [21376794]. | Fruit fly |
| Ilp5 | Insulin-like peptide 5 | Abundance of Ilp5 mRNA is reduced under DR. Ilp5 null mutants have a normal lifespan under AL and a normal DR response. Ilp2 Ilp3 Ilp5 triple null mutants fail to have a normal response to DR. Their response is right shifted, with mutants being shorter-lived compared to wild-type on low but longer-lived on high yeast concentrations [20195512]. | Fruit fly |
| — | (R)-N-(2-heptyl)-N-methylpropargylamine | Addition of 0.66 ng/fly/day (R)-N-(2-heptyl)-N-methylpropargylamine to a sucrose-based diet resulted in no significant effect on lifespan, but lifespan reduction due to galactose feeding is partially suppressed by supplementation with (R)-deprnyl or (R)-N-(2-heptyl)-N-methylpropargylamine [9972869]. | Fruit fly |
| hebe | — | Adult-specific overexpression of hebe increases the lifespan by 5-30% and modulates late-age female fecundity. Female and male mean lifespan is up to 11% and 24% higher [19011900]. | Fruit fly |
| magu | — | Adult-specific overexpression of magu increases lifespan by 5-30% and modulates late-age fecundity [19011900]. | Fruit fly |
| alpha-Man-I | alpha Mannosidase I | alpha-Man-I mutant fly exhibit enhanced resistance to paraquat and starvation an a 60% increase in mean lifespan for both sexes. After outcrossing, the mutant exhibit, under normal conditions, an increase in mean lifespan of 22% for females and 38% for males. Maximum lifespan is increased by 15%. alpha-Man-I RNAi knockdown results in a 39% increase in mean lifespan [19302370]. | Fruit fly |
| Atg2 | Autophagy-specific gene 2 | Atg2 overexpression increases average female lifespan by 28% [18059160]. | Fruit fly |
| Aut1 | — | Aut1 depletion form the first day of imaginal stage shortens lifespan by 28% on average in Drosophila and causes morphological behavioural features of premature aging [18219227]. | Fruit fly |
| bam | bag of marbles | Bam mutants have an extended lifespan due to germ cell loss. Lifespan of females is on average up to 50% higher and that of males on average s up to 27.8% higher [18434551]. | Fruit fly |
| Bmcp | Mitochondrial uncoupler | Bmcp knockout flies live longer on low-calorie diets, have a decreased fertility, and gain less weight on high-calorie diets. Bmcp (ucp5) knockout mutants live longer than wild-type on low-calorie diets, but no longer on starvation or high-calorie diets. Ectopic neuronal expression of Bmcp transgene rescues starvation sensitive phenotype of Bmcp knockout mutants [16387864]. | Fruit fly |
| CG3776 | — | Both overexpression and underexpression of CG3776 (alias Jhebp29) reduces the mean lifespan, where the reduction in males is slightly higher.
The lifespan of male flies with under- and overexpressed CG3776 is reduced by 38.8 and 42.6%, respectively when compared with Oregon R flies.The lifespan of female flies with under- and overexpressed CG3776 is reduced by 31.6 and 35%, respectively when compared to Oregon R flies.
Among the males and females, relatively to Oregon R and EP835/CyO, the age-specific survival of EP835/EP835 and EP835/Gal4 is reduced in both log-rank and Wilcoxon tests (P < 0.001); survival of EP835/EP835 and EP835/Gal4 differed using the log-rank-test (male: P<0.001; female: P=0.027) [18275960].
| Fruit fly |
| bwa | brain washing | bwa (alias Dacer) inactivation increases Drosophila pre-adult development time and anti-oxidative stress capacity. Mean lifespan is increased by 16% in females, by 21% in males and by 19% in total. Maximum lifespan of females, males is also extended by 20 and 12%, respectively [20112046]. | Fruit fly |
| dnc | dunce | cAMP phosphodiesterase-deficient dunce mutants have an extended maximum lifespan by about 70% [17369827]. | Fruit fly |
| Cdk5 | Cyclin-dependent kinase 5 | Cdk5 loss-of-function mutations result in defective axon guidance, age-dependent behavioral deficits and reduced lifespan by about one third [17368005]. | Fruit fly |
| cert | ceramide transfer protein | cert mutants exhibit a shortened lifespan accompanied by enhanced oxidative damage to cellular proteins and metabolic compromise, such as increasing glucose levels, reminiscent of premature aging [17592126]. | Fruit fly |
| CG11015 | — | CG11015 is translational upregulated upon DR. Under rich nutritional conditions lifespan of CG11015 RNAi treated animals is indistinguishable from that of controls, while upon DR, lifespan extension is diminished in males and females [19804760]. | Fruit fly |
| CG12004 | — | CG12004 exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG12016 | — | CG12016 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG12090 | — | CG12090 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG12576 | — | CG12576 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG13306 | — | CG13306 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG13917 | — | CG13917 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG16711 | — | CG16711 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG16718 | — | CG16718 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in abdomen of animals that were selected for longevity [23106705]. | Fruit fly |
