| CTA1 | CaTalase A 1 | CTA1 overexpression partially suppresses the shortened chronological lifespan by ISC1 mutation [21707788]. | Budding yeast |
| DAP2 | Dipeptidyl AminoPeptidase 2 | DAP2 deletion decreases mean and maximum replicative lifespan under AL by 19 and 36%, respectively, and cancels out the lifespan extending effect of moderate DR [22912585]. | Budding yeast |
| CDC13 | Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping | Decreased replicative lifespan | Budding yeast |
| BMH1 | Brain Modulosignalin Homologue 1 | Deleting BMH1 extends chronological lifespan by 25% and is associated with activated stress response, decreased ROS levels and increased heat-shock-element-driven transcription activity. BMH1 deletion was non-additive with the genetic DR mimetic cdc25 and tor1. Water starvation (a form of extreme DR) extends chronological lifespan of BMH1 mutant even more as it does in wild-type. BMH1 genetically interacts with DR as well as TOR- and PKA-signaling pathways to regulate lifespan. Phosphorylation of Ser238 on Bmh1 increases during chronological aging, which is delayed by DR or reduced TOR activity [19805817].
| Budding yeast |
| SNF4 | Sucrose NonFermenting 4 | Deleting SNF4 extends replicative lifespan by 10-20% in S288C strain [10921902].
| Budding yeast |
| RPL43A | Ribosomal Protein of the Large subunit 43A | Deletion decreases mean replicative lifespan by 60% in the alpha strain and by 50% in a strain [18423200] as well as -64% in the ORF collection, but increases mean replicative lifespan by 16% in the remade strain [22377630]. | Budding yeast |
| PHO85 | PHOsphate metabolism 85 | Deletion decreases replicative lifespan by 45% in the alpha strain [18340043], but increases mean chronological lifespan in diploid cells [21447998] | Budding yeast |
| YKU70 | Subunit of the telomeric Ku complex (Yku70p-Yku80p) | Deletion fo YKU70 shortens lifespan, but does not accelerate the normal aging process [10521401]. YKU70 null mutants are defective for non-homologous end-joining [8754818] and for telomeric silencing [9635192]. | Budding yeast |
| RAD52 | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | Deletion in RAD52 causes a 75% reduction in mean replicative lifespan in PSY316 strain [10207108]. Similiar reduction of lifespan occurs in strains W3031-A and W303R [M. Baeberlein, M. McVey, and L. Guarente, unpublished].
RAD51 is required for formation of extrachromosomal rDNA circles [10207108], but not for replication fork pausing nor DNA breakage with the rDNA [10693764]. | Budding yeast |
| RAS1 | — | Deletion in RAS1 increases mean (23%) and maximum (29%) replicative lifespan (in SP1) [8034612]. RAS1 deletion increases replicative lifespan by 15% in the alpha strain [19030232]. However, deletion of RAS1 slightly shortens chronological lifespan (in SP1) [12586694]. No lifespan extension results from overexpression of RAS1 (in SP1) [8034612]. | Budding yeast |
| LOC1 | Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles | Deletion increased mean (25.1 -> 36.7) and maximum replicative lifespan in BY4742 [18423200]. Replicative lifespan increased by 40% in the alpha strain [19030232]. | Budding yeast |
| SSF1 | Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family | Deletion increased mean (25.1 -> 38.5) and maximum replicative lifespan in BY4742 [18423200]. Replicative lifespan increased by 60% in the alpha strain [19030232]. | Budding yeast |
| YPT32 | Yeast Protein Two 32 | Deletion increases mean chronological lifespan by 13 - 45% (13, 17, 45) in diploid cells [21447998]. | Budding yeast |
| PAN2 | Poly(A)-binding protein-dependent poly(A) riboNuclease 2 | Deletion mutant of PAN2 live approximately as long as wild-type under starvation/extreme DR [20657825]. | Budding yeast |
| RPN4 | Regulatory Particle Non-ATPase 4 | Deletion mutants of the C2H2 zinc-finger transcription factor RPN4, are characterized by a reduced non-adaptable proteasome pool and display a 37 - 53% and 22-33% reduction in mean and maximum replicative lifespan. TOR1 deletion extends rpn4 replicative lifespan. Severe DR by reducing glucose concentration to 0.05% increased replicative lifespan of rpn4 mutants. RPN4 transcription is controlled by HSF1 [21931558]. | Budding yeast |
| WHI3 | WHIskey 3 | Deletion of WHI3 decreases replicative lifespan by 25% in the a strain [18340043] and decreases chronological lifespan [21447998 ] | Budding yeast |
| ACO1 | ACOnitase 1 | Deletion of ACO1 decreases mean chronological lifespan by 42 - 56% in diploid cells [21447998]. | Budding yeast |
| ACO2 | ACOnitase 2 | Deletion of ACO2 increases replicative lifespan by 20% in the alpha strain and decreases it by 10% in the a strain [18340043]. Its deletion increases mean chronological lifespan by 6 - 44% (6, 22, 20, 20, 19, 44) in diploid cells [21447998]. | Budding yeast |
| ADE3 | ADEnine requiring 3 | Deletion of ADE3 increases chronological lifespan [20421943]. | Budding yeast |
| ADH1 | Alcohol DeHydrogenase 1 | Deletion of ADH1 increases replicative lifespan by 20% in the alpha strain and 15% in the a strain [18340043]. Adh1 is oxidatively modified during aging and its activity becomes reduced. Overexpression of ADH1 by introducing and extra copy increases mean replicative lifespan by 30% as well as slightly chronological lifespan and was associated with increased Sir2 activity [17975074]. | Budding yeast |
| ADH2 | Alcohol DeHydrogenase 2 | Deletion of ADH2 increases mean chronological lifespan by 6 - 57% (6, 17, 57) in diploid cells [21447998]. | Budding yeast |
| ADH3 | Alcohol DeHydrogenase 3 | Deletion of ADH3 decreases mean chronological lifespan by 15% [21447998]. | Budding yeast |
| AGC1 | Aspartate-Glutamate Carrier | Deletion of AGC1 increases replicative lifespan by 30% in the alpha strain [18340043] and increases mean chronological lifespan by 7 - 28% [21447998]. | Budding yeast |
| AGP1 | high-Affinity Glutamine Permease 1 | Deletion of AGP1 extends chronological lifespan [16418483]. | Budding yeast |
| AKR1 | AnKyrin Repeat-containing protein 1 | Deletion of AKR1 decreases replicative lifespan by 40% in the alpha strain [18340043]. Replicative lifespan decreased by 50% in the alpha strain [19030232]. | Budding yeast |
