| GCN4 | Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels | Deletion of GCN4 increases the replicative lifespan by 10% in the alpha strain [19030232].
GCN4 deletion decreases the lifespan in the alpha and a strain [20657825].
The chronological lifespan of GCN4 deletion is strongly decreased in the a strain [20421943]. | Budding yeast |
| GIS1 | GIg1-2 Suppressor 1 | Deletion of GIS1 increases replicative lifespan by 25% in the alpha strain [19030232] and causes major although not complete reversion of chronological lifespan extension by 0.5% glucose restriction [18225956]. | Budding yeast |
| GLN3 | GLutamiNe metabolism 3 | Deletion of GLN3 extends chronological lifespan [16418483]. GLN3 deletion decreases replicative lifespan by 20% in the alpha strain [19030232]. GLN3 deletion in the vineyard strain dramatically shortens chronological lifespan, while extends that of the laboratory strain [21901113].
| Budding yeast |
| GPA2 | G Protein Alpha subunit 2 | Deletion of GPA2 increases mean and maximum replicative lifespan by 40% and 26%, respectively [11000115]. Deletion of GPA2 extends replicative lifespan by reducing cAMP-PKA activity and provides a genetic model for DR [11000115]. | Budding yeast |
| GPR1 | G-Protein coupled Receptor 1 | Deletion of GRP1 increases mean and maximum replicative lifespan by 41% and 26%, respectively. GRP1 deletion mutants have also longer chronological lifespan. Deletion of GPR1 extends replicative lifespan by reducing cAMP-PKA activity and provides a genetically model for DR [11000115]. | Budding yeast |
| HAC1 | Homologous to Atf/Creb1 1 | Deletion of HAC1 decreases mean, median and maximum replicative lifespan by 10, 8 and 5%, respectively [23167605]. | Budding yeast |
| HES1 | Homologous to kES1 1 | Deletion of HES1 (alias OSH5) extends replicative lifespan and is non-additive with moderate DR. Elevation of OSH5 levels by an ERG6 promoter reduces mean, median and maximum replicative lifespan by 25, 18 and 29%. HES1 is required for the longevity effect of DR, Perg6-OSH6, Perg6-ERG2 and Perg6-OSH7 (genetic mimetics of DR). Hes1 is upregulated in response to sterol down-regulation including DR. Deletion of OSH5 delays different steps of endocytosis, a sterol-requireing process [Xia et al., unpublished].
Perg6-OSH6 osh5 double mutant have a lifespan significantly shorter than that of Perg6-OSH6 [Xia et al. upublished]. | Budding yeast |
| HXK2 | HeXoKinase 2 | Deletion of HXK2 extends mean and maximum replicative lifespan by about 53% and 33%, respectively. Limiting glucose availability by mutating HXK2 significantly extends replicative lifespan and provides a genetically model of DR [11000115]. HXK2 deletion increases oxygene consumption. Changes in gene expression HXK2 mutation are quite similar to those of dietary-restricted cells. In fact, HXK2 mutants have a transcriptional profile that significantly resembles DR cells and cell overexpressing HAP4 [12124627]. | Budding yeast |
| INM1 | INositol Monophosphatase 1 | Deletion of INM1 increases replicative lifespan [16293764]. INM1 deletion results in an replicative lifespan increase by 50% in the alpha strain and a decrease by 10% in a strain [19030232]. | Budding yeast |
| INP51 | INositol polyphosphate 5-Phosphatase 51 | Deletion of INP51 increases replicative lifespan by 10% in the alpha strain and in a strain [18340043; 19030232]. | Budding yeast |
| INP53 | Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains | Deletion of INP53 increases mean replicative lifespan by 31% [16293764]. INP53 deletion increases replicative lifespan by 31% in the alpha strain and by 10% in the a strain [18340043]. | Budding yeast |
| IPK1 | Inositol Polyphosphate Kinase 1 | Deletion of IPK1 increases mean replicative lifespan by 41 - 40% in the alpha strain [16293764; 19030232]. IPK1 deletion extends mean and maximum replicative lifespan by 24 and 19%, respectively, and was non-synergistic with moderate DR [21584246]. | Budding yeast |
| IRC14 | — | Deletion of IRC14 increases mean replicative lifespan by 14-22% [16293764].
IRC14 is a dubious ORF overlapping IDH2. | Budding yeast |
| LCB4 | Long-Chain Base 4 | Deletion of LCB4 increases replicative lifespan and cancels out replicative lifespan extension of 0.5% glucose DR [18690010]. | Budding yeast |
| LIN1 | LINk | Deletion of LIN1 increases replicative lifespan [16293764]. LIN1 deletion increases replicative lifespan by 40% in the alpha strain [19030232]. | Budding yeast |
| LYS9 | LYSine requiring 9 | Deletion of LYS9 increases replicative lifespan [16293764]. LYS9 deletion increases replicative lifespan by 20% in the alpha strain [19030232]. | Budding yeast |
| MEP2 | — | Deletion of MEP2 extends chronological lifespan [16418483]. | Budding yeast |
| MEP3 | — | Deletion of MEP3 extends chronological lifespan [16418483]. | Budding yeast |
| MSN2 | Multicopy suppressor of SNF1 mutation 2 | Deletion of MSN2 and MSN4 extends replicative lifespan and is further extended by cyr1::mTn [14741356]. Deletion of MSN2 and MSN4 does not significantly decrease chronological lifespan under AL, but attenuates chronological lifespan extension by water starvation and 0.5% glucose restriction [18225956] as well as cancels out lifespan extension of cyr1::mTn [14741356] and decreases chronological lifespan extension of ras2 deletion mutant [12586694]. Simultaneous deletion of MSN2 and MSN4 has no effect on chronological lifespan, but prevents lifespan extension by RAS2 deletion [12586694]. msn2 msn4 has no effect on replicative lifespan in PSY316, and does not prevent lifespan extension by DR [11000115] or by high osmolarity [12391171]. | Budding yeast |
| MSN4 | Multicopy suppressor of SNF1 mutation 4 | Deletion of MSN2 and MSN4 extends replicative lifespan and is further extended by cyr1::mTn [14741356]. Deletion of MSN2 and MSN4 does not significantly decrease chronological lifespan under AL, but attenuates chronological lifespan extension by water starvation and 0.5% glucose restriction [18225956] as well as cancels out lifespan extension of cyr1::mTn [14741356] and decreases chronological lifespan extension of ras2 deletion mutant [12586694]. Simultaneous deletion of MSN2 and MSN4 has no effect on chronological lifespan, but prevents lifespan extension by RAS2 deletion [12586694]. msn2 msn4 has no effect on replicative lifespan in PSY316, and does not prevent lifespan extension by DR [11000115] or by high osmolarity [12391171]. | Budding yeast |
| NDI1 | NADH Dehydrogenase Internal 1 | Deletion of NDI1 results in chronological lifespan extension [16436509]. | Budding yeast |
| NMD4 | Nonsense-Mediated mRNA Decay 4 | Deletion of NMD4 increases replicative lifespan [16293764]. NMD4 deletion results in replicative lifespan increase by 25% in the alpha strain and decrease by 20% in a strain [19030232]. | Budding yeast |
| VBA5 | Vacuolar Basic Amino acid transporter 5 | Deletion of of VBA5 increases replicative lifespan by 31% [16293764]. | Budding yeast |
| PIB1 | PhosphatidylInositol(3)-phosphate Binding 1 | Deletion of PIB1 increases replicative lifespan by 25% in the alpha strain [16293764; 19030232]. | Budding yeast |
| PMR1 | High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease | Deletion of PMR1 increses the replicative lifespan by 40% in the alpha strain and by 15% in the a strain. Overexpression of PMR1 extends the lifespan [21918615]. | Budding yeast |
