Denigma

Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
    Fruit fly (27)   Zebrafish (1)   Human (1)  
  • Classifications: + -
    Negative Aging‑Suppressor «  Aging Associated (2)   Aging‑Suppressed (1)   Aging‑Suppressor (27)   Positive Aging‑Suppressor (4)   Gerontogene (2)   Negative Gerontogene (1)   Positive Gerontogene (1)   Longevity‑Associated (1)   DR‑Essential (2)   No Age Effect (1)  
  • Types: + -
    Protein coding «  Gene (29)  
    • symbol name observation species
    Sod2 Superoxide dismutase 2 (Mn) RNA interference of Sod2 results in increased oxidative stress and early-onset mortality in young adults [12456885]. Overexpression of Sod2 by 5-115% decreases lifespan by 4-5% without any compensatory changes in metablic rate, level of physical activity, or the levels of other antioxidants (Sod, Cat, and glutathione) [10545213]. Targeted overexpression of Sod2 in motor neurons alone extends lifespan by 30% [11113599]. Induced overexpression of Sod2 in adult animals extends lifespan up to 37% [12072463]. Overexpression of catalase in combination with SOD2 has no added benefit for lifespan [12072463]. Animals overexpressing SOD2 or catalase do not exhibit a decrease in metabolism as measured by oxgen consumption [12072463]. Sod2 overexpression results in a 20% increase in mean and maximum lifespan [18067683]. Fruit fly
    kermit — The disruption of kermit (alias dGIPC) function results in premature loss of locomotor activity and reduced mean lifespan [21029723]. Fruit fly
    Trx-2 thioredoxin-2 Trx-2 mutants have a 25% reduction in maximum lifespan and exhibit lower tolerance to oxidative stress while animals carrying multiple copies of Trx-2 exhibit higher tolerance [17567437]. Fruit fly
    yata — yata mutation shortens the maximum lifespan by 68% and results in progressive deterioration of the nervous tissues and aberrant accumulation of Sec23 [19209226]. Fruit fly
    Factors are an extension of GenAge and GenDR.

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