| AKAP10 | A kinase (PRKA) anchor protein 10 | Male (n= 4766) and female (n = 6202) divided into young (183-9 years) and old (60 years) groups were examined for polymorphisms. A polymorphism that results in an amino acid change from Ile to Val showed the strongest correlation with age. The Val variant was associated with a statistically significant decrease in the length of the electrocardiogram PR interval. An A to G polymorphism in the 3'UTR of D-AKAP2 showed a significant decrease of the G allele in the older sample of both genders. Additionally, the I646V polymorphism was found to be significantly different between young and old in both males and females [12646697]. | Human |
| WRN | Werner syndrome, RecQ helicase-like | Mutation in WRN causes Werner Syndrome which characteristics includes prematurely aged facies, scleroderma-like skin changes, cataracts, arteriosclerosis, subcutaneous calcification, and diabetes mellitus [McKusick et al. 1963; 5327241]. Inheritance is autosomal recessive and malignancy is frequent. THe frequency is 3 per million individuals in Japan [7460386].
Cells from a Werner heterozygote exit the cell cycle at a faster rate than do normal cells [8265666]. Loss of WRN promoter aberrant mitotic recombination [11316787].
The single nucleotide polymorphism rs1800392 in WRN has been associated with exceptional longevity in a plethora of genetic signatures [22279548]. WRN was found to be associated with longevity [10069711; 20855428; 20855428; 20855428 ;17903295; 22406557; 16405962; 16405962; 16405962; 20855428; 20855428; 20855428; 22279548]. WRN was found to be associated with longevity [24244950]. | Human |
| NTHL1 | nth endonuclease III-like 1 (E. coli) | NTHL1 was found to be associated with longevity [22406557]. | Human |
| NTLH1 | nescient helix loop helix 1 | NTLH1 was found to be associated with longevity [22406557]. | Human |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | olymorphisms in HLA class II alleles of Okinawan centenarians were analyzed. DQA10101=0104 and DQA105 alleles were significantly increased in the centenarians [9389323].HLA-DQA1 was found to be associated with longevity [9389323]. HLA-DQA1 was found to be associated with longevity [9389323]. HLA-DQA1 was not found to be associated with longevity [17714903]. | Human |
| PLXNA1 | plexin A1 | PLXNA1 is significantly associated with longevity [15105583]. | Human |
| POLB | polymerase (DNA directed), beta | POLB was found to be associated with longevity [22406557]. | Human |
| REN | renin | Polymorphic repeats in intron 7 (short and long alleles) were examined in 196 centenarians (143 females and 53 makes) and 358 controls (196 females and 162 male; 10-85 years old). No significant difference in genotype frequencies was found between centenarians and controls [9887369].REN was found to be associated with longevity [15105583]. REN was not found to be associated with longevity [9887369]. | Human |
| PON1 | paraoxonase 1 | Polymorphism at codon 192 (Gln/Arg) of the PON1 gene was examined in 256 healthy Caucasian men (69.8 +/- 4.0 years). Gln homozygotes are more frequent in aging than Arg allele carriers [12889841].PON1 was found to be associated with longevity [15050299]. PON1 was found to be associated with longevity [15050299]. PON1 was found to be associated with longevity [17903295]. PON1 was found to be associated with longevity [12082503]. PON1 was found to be associated with longevity [12082503]. PON1 was found to be associated with longevity [12082503]. PON1 was found to be associated with longevity [16799134]. PON1 was found to be associated with longevity [16799134]. PON1 was found to be associated with longevity [15050299]. PON1 was not found to be associated with longevity [15241482]. PON1 was found to be associated with longevity [15241482]. PON1 was not found to be associated with longevity [20362697]. PON1 was not found to be associated with longevity [18034366]. | Human |
| HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | Polymorphisms in HLA class II alleles of Okinawan centenarians were analyzed. DQB105 and DQB103 alleles were significantly increased in the centenarians [9389323].HLA-DQB1 was found to be associated with longevity [9389323]. HLA-DQB1 was not found to be associated with longevity [17714903]. | Human |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | Polymorphisms in the HLA-DRB1 gene in Okinawan centenarians were analyzed. DRB1*1401 allele was significantly increased in the centenarians while DRB1*0101 and DRB1*1201 alleles were slightly decreased [9389323].HLA-DRB1 was found to be associated with longevity [9425225].HLA-DRB1 was found to be associated with longevity [9425225]. HLA-DRB1 was found to be associated with longevity [9425225]. HLA-DRB1 was found to be associated with longevity [9425225]. HLA-DRB1 was found to be associated with longevity [9389323]. HLA-DRB1 was found to be associated with longevity [12581796]. HLA-DRB1 was found to be associated with longevity [12581796]. HLA-DRB1 was found to be associated with longevity [20426625]. HLA-DRB1 was not found to be associated with longevity [16269080]. | Human |
| TH | tyrosine hydroxylase | Polymorphyc repeats in intron 1 (Short and Long alleles) of the TH gene were examined in 196 centenarians (143 females and 53 males) and 358 controls (196 females and 162 male; 10-85 years old). A significant loss of LL homozygous genotypes was found at the THO locus in male but not in female centenarians with respect to matched controls [9887369].TH was found to be associated with longevity [12297342]. TH was found to be associated with longevity [21407269]. TH was found to be associated with longevity [19367319]. TH was not found to be associated with longevity [19367319]. TH was found to be associated with longevity [11053670]. TH was found to be associated with longevity [17989723]. | Human |
| RAD23B | RAD23 homolog B (S. cerevisiae) | RAD23B was found to be associated with longevity [22406557]. | Human |
| RAD52 | RAD52 homolog (S. cerevisiae) | RAD52 was found to be associated with longevity [22406557]. | Human |
| RIMBP2 | RIMS binding protein 2 | RIMBP2 was found to be associated with longevity [22174011]. | Human |
| APOC3 | apolipoprotein C-III | Several small nucleotide polymorphisms in the APOC3 gene were associated with longevity [8018664; 11193221; 16602826].
The Sst I polymorphism was examined in 179 Finnish centenarians. The S2 allele (Sst I restriction site present) occurred more often in the centenarians (frequency, 12.9%) than in the youngest reference population (frequency, 8.8%) [8018664]. | Human |
| SIRT1 | sirtuin 1 | SIRT1 was found to be associated with longevity [21972126; 16257164; 16257164; 16257164; 16257164; 16257164; 21972126; 20633545]. SIRT1 was not found to be associated with longevity [16257164; 18765803].SIRT1 was found to be associated with longevity [23505545]. SIRT1 was found to be associated with longevity [23450480]. SIRT1 was not found to be associated with longevity [23450480]. | Human |
| QKI | quaking homolog, KH domain RNA binding (mouse) | SNPs close to SQKI were associated with longevity [22773346]. | Human |
| PDE10A | phosphodiesterase 10A | SNPs near PDE10A were associated to longevity [22773346]. | Human |
| IL10 | interleukin 10 | The -1082G/A, -819C/T and -592C/A proximal promoter SNPs of the IL10 gene were examined in 190 centenarians (>99 years old, 159 women and 31 men) and in 260 control subjects (99 women and 161 men less than 60 years old). The -1082G homozygous genotype, associated with high IL-10 production, was increased in centenarian men but not in centenarian women. No difference was found between centenarians and control subjects regarding the other two SNPs [11857058].IL10 was found to be associated with longevity [20518833]. IL10 was found to be associated with longevity [12676903]. IL10 was found to be associated with longevity [12676903]. IL10 was found to be associated with longevity [11640949]. IL10 was found to be associated with longevity [21299522]. IL10 was found to be associated with longevity [21299522]. IL10 was found to be associated with longevity [11857058]. IL10 was found to be associated with longevity [15466015]. IL10 was not found to be associated with longevity [11640949]. | Human |
| HSPA1B | heat shock 70kDa protein 1A | The A/G (1267 coding) polymorphism in the HSPA1B was examined in 426 participants of various ages Female carriers of GG genotype survive better than noncarriers [16804002]. | Human |
| IFNG | interferon, gamma | The distribution of 874T/A polymorphism in the IFNG gene was examined in 174 Italian centenarians (>99 years old, 142 women and 32 men) and 248 <60-year-old control subjects (90 women and 158 men). The +874T allele, known to be associated with low IFN-gamma production, was found less frequently in centenarian women than in centenarian men or in control women whereas no significant differences were observed in the distribution of the two alleles between male or female controls. Allele frequencies in centenarian men were not found significantly different from male controls [11772518].IFNG was found to be associated with longevity [21299522]. IFNG was not found to be associated with longevity [11772518]. IFNG was found to be associated with longevity [11772518]. | Human |
| PCMT1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | The distribution of genotypes in a healthy older population of Ashenazi Jewish individuals with that in a younger ethnically matched control group were compared. 65% of the healthy older population had the heterozygous genotype, greater than the 50% expected by Hardy-Weinberg equilibrium, suggesting a possible selection for having both alleles of the repair methyltransferase in successful aging [10496068].PCMT1 was found to be associated with longevity [10496068]. | Human |
| TNF | tumor necrosis factor | The frequency of the -308 polymorphism in the TNF gene was analyzed in 71 healthy elders, aged 80 to 96 years (mean 86.2 years). The control samples were obtained from 99 young (from 21 - 54 years; mean 35.2 years) healthy individuals unrelated to elders were studied, age ranged from 80 to 96 years (mean 86.2 years). The TNF2 allele was increased in the elder group when compared to young controls [16269080].TNF was found to be associated with longevity [20518833]. TNF was found to be associated with longevity [18511747]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12676903]. TNF was found to be associated with longevity [11640949]. TNF was found to be associated with longevity [21299522]. TNF was found to be associated with longevity [21299522]. TNF was not found to be associated with longevity [12676903]. TNF was found to be associated with longevity [16269080]. TNF was not found to be associated with longevity [11640949]. | Human |
| HSPA1L | heat shock 70kDa protein 1-like | The frequency of the T2437C transversion (Met to Thr) polymorphism in the HSPA1L gene was investigated in a healthy aged population of 100 control samples (59% female, 41% male with an age-range of 19-45 years) and 129 aged consecutive samples (70% female, 30% male with an age range of 80-97 years). The 2437T polymorphic nucleotide was observed to increase in the elderly, although not attaining statistical significance. The TT genotype was observed to be significantly increased within the aged population, while conversely the TC genotype was significantly decreased in the aged subjects [12742533].HSPA1L was found to be associated with longevity [12742533]. HSPA1L was found to be associated with longevity [16804002]. HSPA1L was found to be associated with longevity [16804002]. | Human |
