Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
  • symbol name observation species
    Fhos Fhos exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fhos is upregulated under microbial infection [12431377] and downregulated with age [17196240]. Fruit fly
    CG4726 CG4726 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fruit fly
    CG6041 CG6041 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fruit fly
    CG6048 CG6048 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fruit fly
    CG12004 CG12004 exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    CG6511 CG6511 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fruit fly
    CG13306 CG13306 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fruit fly
    CG34426 CG34426 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fruit fly
    CG5194 CG5194 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fruit fly
    Doc1 Doc1 exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in the abdomen of for longevity selected lines [23106705]. Fruit fly
    Tequila Tequila exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Tequila is upregulated with age and microbial infection, while downregulated with oxidative stress [11095759; 17196240; 15475297]. Fruit fly
    CG12090 CG12090 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    CG7852 CG7852 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head and abdomen of animals that were selected for longevity [23106705]. Fruit fly
    CG13917 CG13917 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    CG12016 CG12016 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    CG16711 CG16711 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    CG4942 CG4942 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    CG32022 CG32022 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    CG12576 CG12576 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    CG6184 CG6184 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    CG6195 CG6195 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in abdomen of animals that were selected for longevity [23106705]. Fruit fly
    CG16718 CG16718 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in abdomen of animals that were selected for longevity [23106705]. Fruit fly
    CG34243 CG34243 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    CLU clusterin Overexpression of the secretory form of human Clusterin in fruit flies increases mean lifespan. hClu overexpression flies also have greater tolerance to heat shock, wet starvation, and oxidative stress and the whole body amounts of reactive oxygen species is lower [22465014].CLU was found to be associated with longevity [16804001]. Fruit fly
    Cct1 CTP:phosphocholine cytidylyltransferase 1 Overexpression of Cct1 from a doxycycline-inducible promoter results in a 6 - 8% increase in mean lifespan (in the PdL x rtTA; Oregon-R x rtTA strain) [12620118]. Cct1 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is upregulated in head of animals that were selected for longevity at all ages beyond the day of eclosion [23106705]. Fruit fly
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    • 25 of 39 factors
    Factors are an extension of GenAge and GenDR.

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