Denigma

Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
    Budding yeast « 
  • Classifications: + -
    Aging Associated (23)   Aging‑Suppressor (154)   Negative Aging‑Suppressor (127)   Positive Aging‑Suppressor (37)   Gero‑Suppressant (3)   Gerontogene (128)   Negative Gerontogene (11)   Positive Gerontogene (122)   DR‑Differential (1)   DR‑Induced (4)   DR‑Essential (80)   DR‑Essential Paralog (1)   No Age Effect (27)  
  • Types: + -
    Gene (2)  
    • symbol name observation species
    RRG1 — Deletion of RRG1 decreases replicative lifespan by 50% in the alpha strain [19030232]. Budding yeast
    YDR089W — Deletion of YDR089W decreases replicative lifespan by 30% in the alpha strain [19030232]. Budding yeast
    YDR124W — Deletion of YDR124W increases replicative lifespan by 30% in the alpha and decreases lifespan by 10% in a strain [19030232]. Budding yeast
    YDR132C — Deletion of YDR132C decreases replicative lifespan by 35% in the alpha strain [19030232]. Budding yeast
    YBR238C — Deletion of YBR238C increases mean replicative lifespan by 25 to 34% in the alpha and a strains [16293764; 19030232]. Budding yeast
    YDR248C — Deletion of YDR248C increases replicative lifespan by 20% in the alpha strain [19030232]. Budding yeast
    YDR262W — Deletion of YDR262W decreases replicative lifespan by 30% in the alpha strain [19030232]. Budding yeast
    YDR307W — Deletion of YDR307W increases replicative lifespan by 30% in the alpha strain [19030232]. Budding yeast
    YER186C — Deletion of YER186C increases replicative lifespan by 30% in the alpha strain [19030232]. Budding yeast
    YER187W — Deletion of YER187W increases replicative lifespan by 30% in the alpha strain [19030232]. Budding yeast
    YGL235W — YGL235W increases replicative lifespan by 20% in the alpha strain [19030232]. Budding yeast
    YGR071C — Deletion of YGR071C decreases replicative lifespan by 60% in the alpha strain [19030232]. Budding yeast
    YGR130C — Deletion of YGR130C increases replicative lifespan increased by 30% in the alpha strain and increased by 20% in the a strain [18340043], as well as mean and maximum chronological lifespan by 18 and 50%, respectively [22216232] Budding yeast
    ANS1 — Deletion of ANS1 decreases replicative lifespan by 25% in the alpha strain [19030232]. Budding yeast
    YIA6 — Deletion of YIA6 decreases replicative lifespan by 30% in the a strain [18340043]. Budding yeast
    RAD27 — Deletion of RAD27 results in signs of premature aging and approximately 60% reduction in mean replicative lifespan [12024027]. Budding yeast
    YKL069W — Deletion of YKL069W increases sensitivity to oxidative stress and decreases replicative lifespan [19049972]. Budding yeast
    RAD57 — Mutations result in a 40% reduced lifespan. Budding yeast
    YLR422W — Deletion of YLR422W increases replicative lifespan by 25% in the alpha strain [19030232]. Budding yeast
    HSC80 — Deletion of HSC82 has no effect on replicative lifespan, but shortens chronological lifespan [11361336]. Budding yeast
    RAS1 — Deletion in RAS1 increases mean (23%) and maximum (29%) replicative lifespan (in SP1) [8034612]. RAS1 deletion increases replicative lifespan by 15% in the alpha strain [19030232]. However, deletion of RAS1 slightly shortens chronological lifespan (in SP1) [12586694]. No lifespan extension results from overexpression of RAS1 (in SP1) [8034612]. Budding yeast
    YLR460C — Deletion of YLR460C decreases replicative lifespan by 30% in the alpha strain [19030232]. Budding yeast
    YMR010W — Deletion of YMR010W increases replicative lifespan by 30% in the alpha strain [18340043]. Budding yeast
    YMR018W — Deletion of YMR018W increases replicative lifespan by 35% in the alpha strain [18340043]. Budding yeast
    YMR166C — Deletion of YMR166C decreases replicative lifespan by 20% in the alpha strain [18340043]. Budding yeast
    • Page 1 of 25
    • 25 of 605 factors
    Factors are an extension of GenAge and GenDR.

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