| Y48G1A.4 | — | RNA interference in adulthood extended mean lifespan by 21%. | Nematode |
| Y47G6A.18 | — | RNA interference decreased median lifespan by 28% in a daf-2 background and 12% in daf-2/daf-16 double mutants. | Nematode |
| Y47D3A | — | RNAi against Y47D3A.29 decreases mean and maximum lifespan by 19-26% and 34% [18059442]. | Nematode |
| Y46H3C.6 | — | RNA interference extends lifespan. | Nematode |
| Y46G5A.6 | phi-3 | RNA interference of Y46G5A.6 in adulthood shortens the extends lifespan of daf-2(mu150) mutants. Only a negligible or small reduction in the lifespan of wild-type worms occurs by knockdown of Y46G5A.6 [17392428]. | Nematode |
| Y43H11AL.2 | — | RNA interference extends lifespan. | Nematode |
| Y43F8B.12 | — | RNA interference extends lifespan. | Nematode |
| Y43F4B.7 | — | RNA interference increased mean lifespan by 11%. | Nematode |
| Y42G9A.4 | Y42G9A.4b | RNA interference decreased median lifespan by 14% in wild type animals and 33% in daf-2 mutants. | Nematode |
| Y41E3.11 | human FANCD2 (Fanconi's anemia defect) ortholog | Y41E3.11 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| Y39H10A.6 | — | RNA interference extends lifespan. | Nematode |
| Y39G10AR.8 | — | RNA interference in adulthood extended mean lifespan by 24%. | Nematode |
| Y39F10C.1 | — | RNA interference extends lifespan. | Nematode |
| Y37D8A.18 | — | RNA interference increased mean lifespan by 39%. | Nematode |
| Y37D8A.12 | — | RNA interference extends lifespan. | Nematode |
| Y105C5B.12 | — | RNA interference in adulthood extended mean lifespan by 27%. | Nematode |
| xrn-1 | XRN (mouse/S. cerevisiae) ribonuclease related | xrn-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| wwp-1 | WW domain Protein (E3 ubiquitin ligase) 1 | RNA interference of wwp-1 decreases median lifespan by 9% in wild-type animals and 24% in daf-2 mutants [18006689]. Loss of wwp-1 function by RNAi or mutation reduces lifespan at 25 degree Celsius, but not 20 degree Celsius. wwp-1 overexpression extends lifespan by up to 20%. Reduced levels of wwp-1 completely suppress the extended longevity of eat-2 mutants. Lifespan of wwp-1 mutants across entire food concentration range by bacterial dilution in liquid culture or on solid plates does not noticeable change. There is no difference in wwp-1 mRNA levels under AL and DR. RNAi reduction of pha-4, but not of daf-16 suppresses increased longevity by wwp-1 overexpression. Mutations in iron sulphur component of complex III, isp-1, increases longevity by reducing mitochondrial function. wwp-1 RNAi does not suppress the extended lifespan of isp-1 mutants and has only minor suppressive effects on lifespan of another mitochondrial mutant, clk-1, and in cyc-1 RNAi treated worms. RNAi depletion of wwp-1 has no effect on long lifespan of daf-2 mutants [19553937]. | Nematode |
| wts-1 | WarTS (Drosophila) protein kinase homolog 1 | RNA interference of wts-1 in adulthood extends mean lifespan by 21% [17411345]. | Nematode |
| wrn-1 | human WRN (Werner's syndrome) related | RNAi kockdown of wrn-1 shortens the lifespan, increases sensitivity to DNA damage, and accelerates aging phenoypes [15115755].
A nonfunctional wrn-1 DNA helicase decreases the lifespan. The expression of miR-124 in whole wrn-1 mutant worms is significantly reduced. Supplementation with vitamin C normalizes the median lifespan of wnr-1 and mir-124 mutants [23075628]. | Nematode |
| wnk-1 | mammalian WNK-type protein kinase homolog 1 | RNA interference of wnk-1 decreases lifespan by 9% and suppresses lifespan extension by eat-2 mutation [22829775]. | Nematode |
| wip-1 | Wiskott-Aldrich syndrome protein (WASP)-Interacting Protein and gene assignment | RNA interference decreased median lifespan by 33% in daf-2 mutants. | Nematode |
| wdr-23 | WD Repeat protein 23 | RNA interference of wdr-23 in adulthood extends mean lifespan by 24% [17411345]. | Nematode |
| wah-1 | Worm AIF (apoptosis inducing factor) Homolog | wah-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. RNAi against wah-1 started after the animal reaches the late L4 stage extends mean lifespan by 7-8% [22103665]. | Nematode |
| W09D10.3 | — | RNA interference increased mean lifespan by 51%. | Nematode |
