| YKU70 | Subunit of the telomeric Ku complex (Yku70p-Yku80p) | Deletion fo YKU70 shortens lifespan, but does not accelerate the normal aging process [10521401]. YKU70 null mutants are defective for non-homologous end-joining [8754818] and for telomeric silencing [9635192]. | Budding yeast |
| YKL069W | — | Deletion of YKL069W increases sensitivity to oxidative stress and decreases replicative lifespan [19049972]. | Budding yeast |
| YIA6 | — | Deletion of YIA6 decreases replicative lifespan by 30% in the a strain [18340043]. | Budding yeast |
| YHC3 | Yeast Homolog of human Cln3 | YHC3 deletion decreases 10-20% shortened lifespan [16435200]. | Budding yeast |
| YHB4 | Yeast HemogloBin-like protein 4 | sfa1;yhb1 double mutant cancels out the ability of moderate DR to extend replicative lifespan, but not chronological lifespan. Indicating that NO homeostasis during DR-induced replicative lifespan extension is crucial. Deleting YHB1 partially abolished DR-induced replicative lifespan extension, whereas deleting SFA1 alone had no effect. Yhb1 and Sfa1 may play redundant roles [21584246]. | Budding yeast |
| YGR130C | — | Deletion of YGR130C increases replicative lifespan increased by 30% in the alpha strain and increased by 20% in the a strain [18340043], as well as mean and maximum chronological lifespan by 18 and 50%, respectively [22216232] | Budding yeast |
| YGR071C | — | Deletion of YGR071C decreases replicative lifespan by 60% in the alpha strain [19030232]. | Budding yeast |
| YGL235W | — | YGL235W increases replicative lifespan by 20% in the alpha strain [19030232]. | Budding yeast |
| YFH1 | Yeast Frataxin Homolog 1 | Deletion of YFH1 decreases replicative lifespan by 50% [15130665]. | Budding yeast |
| YER187W | — | Deletion of YER187W increases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
| YER186C | — | Deletion of YER186C increases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
| YDR417C | — | Deletion of YDR417C increased chronological lifespan [20657825]. | Budding yeast |
| YDR307W | — | Deletion of YDR307W increases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
| YDR262W | — | Deletion of YDR262W decreases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
| YDR248C | — | Deletion of YDR248C increases replicative lifespan by 20% in the alpha strain [19030232]. | Budding yeast |
| YDR132C | — | Deletion of YDR132C decreases replicative lifespan by 35% in the alpha strain [19030232]. | Budding yeast |
| YDR124W | — | Deletion of YDR124W increases replicative lifespan by 30% in the alpha and decreases lifespan by 10% in a strain [19030232]. | Budding yeast |
| YDR089W | — | Deletion of YDR089W decreases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
| YDL180W | — | YDL180W deletion impairs DR-mediated replicative lifespan extension, but does not change lifespan on AL significantly [22912585]. | Budding yeast |
| YDL041W | — | Deletion of YDL041W increases chronological lifespan by 19 - 29% (19, 19, 27, 29) in diploid cells [21447998]. | Budding yeast |
| YDC1 | Yeast DihydroCeramidase 1 | Overexpression of YDC1 decreases chronological lifespan by 40% [19059240] | Budding yeast |
| YBR238C | — | Deletion of YBR238C increases mean replicative lifespan by 25 to 34% in the alpha and a strains [16293764; 19030232]. | Budding yeast |
| YBR225W | — | Deletion of YBR225W decreases replicative lifespan by 40% in the alpha strain [19030232]. | Budding yeast |
| WSC4 | cell Wall integrity and Stress response Component 4 | Deletion of WSC4 decreases replicative lifespan by 30% in the alpha strain [18340043]. | Budding yeast |
| WHI3 | WHIskey 3 | Deletion of WHI3 decreases replicative lifespan by 25% in the a strain [18340043] and decreases chronological lifespan [21447998 ] | Budding yeast |
