| YPT32 | Yeast Protein Two 32 | Deletion increases mean chronological lifespan by 13 - 45% (13, 17, 45) in diploid cells [21447998]. | Budding yeast |
| YPR011C | — | Deletion of YPR011V decreases replicative lifespan by 20% in the a strain [18340043]. | Budding yeast |
| YPK1 | Yeast Protein Kinase 1 | Deletion of YPK1 decreases replicative lifespan by 20% in the alpha strain [18340043]. | Budding yeast |
| YPC1 | Yeast Phyto-Ceramidase 1 | Deletion of YPC1 decreases replicative lifespan by 15% in the alpha strain [19030232]. | Budding yeast |
| YOS9 | Yeast OS-9 homolog | Deletion of YOS9 decreases replicative lifespan by 10% in the alpha strain [19030232]. | Budding yeast |
| YOR1 | Yeast Oligomycin Resistance 1 | Deletion of YOR1 increases mean chronological lifespan by 21 - 25% (21, 24, 25) in diploid cells [21447998]. | Budding yeast |
| YOL092W | — | Deletion of YOL092W decreases mean and maximum replicative lifespan by 36 and 21%, respectively. Lifespan of YOL092Y deletion mutants is extended by 0.5% glucose restriction [22912585]. | Budding yeast |
| YNR066C | — | Deletion of YNR066C decrease replicative lifespan by 50% in the alpha strain [19030232]. | Budding yeast |
| YMR226C | — | Replicative lifespan of TMA29 mutants increases by 35% in the alpha strain and decreases by 10% in the a strain [18340043]. | Budding yeast |
| YMR166C | — | Deletion of YMR166C decreases replicative lifespan by 20% in the alpha strain [18340043]. | Budding yeast |
| YMR018W | — | Deletion of YMR018W increases replicative lifespan by 35% in the alpha strain [18340043]. | Budding yeast |
| YMR010W | — | Deletion of YMR010W increases replicative lifespan by 30% in the alpha strain [18340043]. | Budding yeast |
| YME1 | Yeast Mitochondrial Escape 1 | Deletion of YME1 decreases chronological lifespan by 50% [17492370] as well as replicative lifespan by 45% in the alpha strain [18340043]. | Budding yeast |
| YLR460C | — | Deletion of YLR460C decreases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
| YLR422W | — | Deletion of YLR422W increases replicative lifespan by 25% in the alpha strain [19030232]. | Budding yeast |
| YKU80 | Subunit of the telomeric Ku complex (Yku70p-Yku80p) | Deletion of YKU80 significantly shortens replicative lifespan, but does not accelerate the normal aging process [10521401]. YKU80 null mutant is defective for non-homologous end-joining [8754818] and for telomere silincing [9501103; 9635192] | Budding yeast |
| YKU70 | Subunit of the telomeric Ku complex (Yku70p-Yku80p) | Deletion fo YKU70 shortens lifespan, but does not accelerate the normal aging process [10521401]. YKU70 null mutants are defective for non-homologous end-joining [8754818] and for telomeric silencing [9635192]. | Budding yeast |
| YKL069W | — | Deletion of YKL069W increases sensitivity to oxidative stress and decreases replicative lifespan [19049972]. | Budding yeast |
| YIA6 | — | Deletion of YIA6 decreases replicative lifespan by 30% in the a strain [18340043]. | Budding yeast |
| YHC3 | Yeast Homolog of human Cln3 | YHC3 deletion decreases 10-20% shortened lifespan [16435200]. | Budding yeast |
| YHB4 | Yeast HemogloBin-like protein 4 | sfa1;yhb1 double mutant cancels out the ability of moderate DR to extend replicative lifespan, but not chronological lifespan. Indicating that NO homeostasis during DR-induced replicative lifespan extension is crucial. Deleting YHB1 partially abolished DR-induced replicative lifespan extension, whereas deleting SFA1 alone had no effect. Yhb1 and Sfa1 may play redundant roles [21584246]. | Budding yeast |
| YGR130C | — | Deletion of YGR130C increases replicative lifespan increased by 30% in the alpha strain and increased by 20% in the a strain [18340043], as well as mean and maximum chronological lifespan by 18 and 50%, respectively [22216232] | Budding yeast |
| YGR071C | — | Deletion of YGR071C decreases replicative lifespan by 60% in the alpha strain [19030232]. | Budding yeast |
| YGL235W | — | YGL235W increases replicative lifespan by 20% in the alpha strain [19030232]. | Budding yeast |
| YFH1 | Yeast Frataxin Homolog 1 | Deletion of YFH1 decreases replicative lifespan by 50% [15130665]. | Budding yeast |
