Denigma

Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
    Human « 
  • Classifications: + -
    No Age Effect «  Aging Associated (2)   Aging‑Suppressor (1)   Positive Aging‑Suppressor (1)   Longevity‑Associated (28)  
  • Types: + -
    Gene «  Protein coding (32)  
    • symbol name observation species
    C4B complement component 4B (Chido blood group) Genetic variations in C4B are not associated with longevity in Italian [10219002]. Human
    C4A complement component 4A (Rodgers blood group) Genetic variations in C4A are not associated with longevity in Italian [10219002]. Human
    C3 complement component 3 Genetic variations in C3 are not associated with longevity in Italian [10219002]. Human
    INS insulin Expression of human insulin under an inducible heat shock promoter increases nematode lifespan by 25% and is also able to enhance the lifespan of daf-2 mutants [11274053]. INS was found to be associated with longevity [22406557; 19367319; 17989723; 19489743]. Human
    GSTT1 glutathione S-transferase theta 1 Deletion in the GSTT1 was examined in 94 nonagenarians and centenarians and 418 control subjects of younger age. A significant difference in the proportion of nonagenarians and centenarians homozygotes for the deletion was observed in comparison to control subjects [11162685].GSTT1 was found to be associated with longevity [11162685]. GSTT1 was found to be associated with longevity [16574194]. GSTT1 was not found to be associated with longevity [11162685]. GSTT1 was not found to be associated with longevity [15195682]. Human
    HFE hemochromatosis C282Y, H63D and S65C polymorphisms in the HFE gene were studied in 106 young controls (age range from 22 to 55 years; 40 men and 66 women) and 35 elderly subjects (age range from 91 to 105 years; seven men and 28 women). A significant difference was observed only in women in frequencies of C282Y alleles between the young and the elderly subjects. Concerning H63D polymorphisms, no significant differences were observed, between old and young people [11857056].HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [12714263]. HFE was not found to be associated with longevity [11857056]. HFE was not found to be associated with longevity [12714263]. Human
    IGF2 insulin-like growth factor 2 (somatomedin A) A/G ApaI site SNP in the IGF2 gene was examined in 224 older (75 years) Jewish Jerusalem residents of Ashkenazi ethnicity (150 males and 74 females) and a group of 441 younger subjects (22 years). An increase in the A allele was observed in older Ashkenazi females and a highly significant increase was observed in the AA genotype in these subjects [15621215].IGF2 was found to be associated with longevity [19367319]. IGF2 was not found to be associated with longevity [19367319]. IGF2 was found to be associated with longevity [17989723]. IGF2 was found to be associated with longevity [15621215]. Human
    APOB apolipoprotein B (including Ag(x) antigen) A sample of 143 centenarians and a control sample of 158 individuals were examined for polymorphism in APOB restriction fragment length (RFLP) (XbaI2488 and EcoRI4154) and variable number of tandem repeat (VNTR) (3'APOB-VNTR) polymorphisms. Neither the XbaI-RFLP nor the EcoRI-RFLP was able to discriminate between centenarians and controls, while the 3'APOB-VNTR multiallelic system revealed significant differences between the samples: the frequency of alleles with fewer than 35 repeats was lower in centenarians than in controls [9050915].apoB was found to be associated with longevity [17393087].APOB was found to be associated with longevity [15028112]. APOB was found to be associated with longevity [17393087]. APOB was not found to be associated with longevity [17393087]. APOB was found to be associated with longevity [9050915]. APOB was not found to be associated with longevity [11592926]. APOB was not found to be associated with longevity [8018664]. APOB was not found to be associated with longevity [9050915]. Human
    INSR insulin receptor 5 intronic and 1 exonic polymorphisms in the INSR gene were examined in 122 semisupercentenarians (older than 105, 107 female, 15 male, mean age 106.8 years) and 122 healthy younger controls (105 female, 17 male, mean age 33.33). One haplotype, which was comprised of 2 intronic SNPs in linkage disequilibrium, was more frequent in semisupercentenarians than in younger controls [15582274].INSR was found to be associated with longevity [15582274]. INSR was not found to be associated with longevity [15582274]. INSR was not found to be associated with longevity [19489743]. Human
    Factors are an extension of GenAge and GenDR.

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