Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
  • symbol name observation species
    ZWINT ZW10 interactor ZWINT was found to be associated with longevity [22279548]. Human
    ZNF331 zinc finger protein 331 ZNF331 was found to be associated with longevity [21782286]. Human
    ZBTB20 zinc finger and BTB domain containing 20 ZBTB20 was found to be associated with longevity [22279548]. Human
    XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) XRCC5 was found to be associated with longevity [22406557; 16518718]. Human
    XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 XRCC4 was found to be associated with longevity [16518718]. Human
    XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 XRCC3 was found to be associated with longevity [16518718]. Human
    XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 XRCC1 was found to be associated with longevity [16518718]. Human
    XKR6 XK, Kell blood group complex subunit-related family, member 6 XKR6 was found to be associated with longevity [22279548]. Human
    XDH xanthine dehydrogenase XDH was found to be associated with longevity [22406557; 22279548]. Human
    WWOX WW domain containing oxidoreductase WWOX was found to be associated with longevity [22279548]. WWOX was found to be associated with longevity [24244950]. Human
    WDR72 WD repeat domain 72 WDR72 was found to be associated with longevity [22279548]. Human
    VWA5A von Willebrand factor A domain containing 5A VWA5A was found to be associated with longevity [21782286]. Human
    VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) VPS13D was found to be associated with longevity [22279548]. Human
    VEGFA vascular endothelial growth factor A VEGFA was found to be associated with longevity [17574707]. VEGFA was not found to be associated with longevity [17574707]. Human
    VDR vitamin D (1,25- dihydroxyvitamin D3) receptor VDR was found to be associated with longevity [21051524]. VDR was not found to be associated with longevity [20407924]. VDR was found to be associated with longevity [20407924]. Human
    VASH1 vasohibin 1 VASH1 was found to be associated with longevity [22279548]. Human
    upstream of FOXO3A upstream of FOXO3A was found to be associated with longevity [19196970]. Human
    Upstram of FOXO3A Upstram of FOXO3A was found to be associated with longevity [19196970]. Human
    UCP3 uncoupling protein 3 (mitochondrial, proton carrier) UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. Human
    UCP1 uncoupling protein 1 (mitochondrial, proton carrier) UCP1 was found to be associated with longevity [21827845]. Human
    UCK2 uridine-cytidine kinase 2 UCK2 was found to be associated with longevity [22445811]. Human
    UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) UBE2H was found to be associated with longevity [22279548]. Human
    TXNRD1 thioredoxin reductase 1 TXNRD1 was found to be associated with longevity [22406557]. Human
    TSHR thyroid stimulating hormone receptor Two single nucleotide in the TSHR were associated with increased TSH in both centenarians and their offspring [19837933].TSHR was found to be associated with longevity [19837933]. TSHR was not found to be associated with longevity [19837933]. Human
    APOA4 apolipoprotein A-IV Two restriction polymorphisms, HinfI347 (Thr347/Ser) and Fnu4HI360 (Gln360/His), and a VNTR (alleles 3, 4) at the 3 region of the APOA4 gene were examined in 71 centenarians (18 men and 53 women, 100-107 years of age, mean 102.3 years) and 100 unrelated adults (21 men and 79 women, 19-59 years of age, mean 35.7 years). The Hinf347 genotype distribution was significantly different in centenarians [9622284].APOA4 was found to be associated with longevity [9533408]. APOA4 was found to be associated with longevity [9622284]. APOA4 was not found to be associated with longevity [9622284]. APOA4 was not found to be associated with longevity [12556235]. Human
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    • 25 of 467 factors
    Factors are an extension of GenAge and GenDR.

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