| zyg-11 | ZYGote defective: embryonic lethal | zyg-11 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| ztf-12 | Zinc finger Transcription Factor family | RNA interference of ztf-12 results in a shortened lifespan. ztf-12 is a target of daf-16 [16380712]. | Nematode |
| ZC395.10 | Zinc finger Transcription Factor family | ZC395.10 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| zfp-1 | Zinc Finger Protein | RNA interference shortened lifespan. | Nematode |
| sir-2.4 | yeast SIR related 2.4 | RNA interference against sir-2.4 or overexpression of SIR-2.4 do not change the mean or maximum lifespan. Neither sir-2.4 RNAi nor SIR-2.4 overexpression affects the increased lifespan of daf-2(e1370) mutants [Tishkoff et al. 2012]. | Nematode |
| sir-2.1 | Yeast SIR related 1 | sir-2.1 deletion slightly reduces lifespan of wild-type [16860373]. sir-2.1 overexpression extends lifespan by about 50% and this lifespan extension depends on DAF-16 activity as it is suppressed by mutation in daf-16 and it does not synergize with daf-2 [11242085]. sir-2.1 suppresses longevity of unc-13 and eat-2, but not daf-2 or unc-64 mutants. sir-2.1 is therefore partially required for lifespan extension from mutation of eat-2 [16860373], but is completely independent for lifespan extension from DR using a reduced feeding protocol [Kaeberlein et al. in press]. sDR increases lifespan of wild-type and sir-2.1 mutants to the same extent [19239417].
Overrexpression of sir-2.1 synergizes with TGF-beta mutation (daf-4 and daf-1) for dauer formation [11242085]. | Nematode |
| ndc-80 | Yeast NDC (nuclear division cycle) homolog) | ndc-80 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| mcm-2 | yeast MCM (licensing factor) related | RNA interference in adulthood resulted in a 15% mean lifespan extension. | Nematode |
| F43G9.5 | yeast Enhancer of DeCapping homolog | F43G9.5 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| bub-3 | yeast BUB homolog | RNAi against bub-3 increases mean and maximum lifespan by 6-7% and 7%, respectively [18059442]. | Nematode |
| Y77E11A.7 | Y77E11A.7b | RNA interference decreased median lifespan by 24% in wild type animals, 40% in a daf-2 background and 13% in daf-2/daf-16 double mutants. | Nematode |
| Y42G9A.4 | Y42G9A.4b | RNA interference decreased median lifespan by 14% in wild type animals and 33% in daf-2 mutants. | Nematode |
| xrn-1 | XRN (mouse/S. cerevisiae) ribonuclease related | xrn-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| wwp-1 | WW domain Protein (E3 ubiquitin ligase) 1 | RNA interference of wwp-1 decreases median lifespan by 9% in wild-type animals and 24% in daf-2 mutants [18006689]. Loss of wwp-1 function by RNAi or mutation reduces lifespan at 25 degree Celsius, but not 20 degree Celsius. wwp-1 overexpression extends lifespan by up to 20%. Reduced levels of wwp-1 completely suppress the extended longevity of eat-2 mutants. Lifespan of wwp-1 mutants across entire food concentration range by bacterial dilution in liquid culture or on solid plates does not noticeable change. There is no difference in wwp-1 mRNA levels under AL and DR. RNAi reduction of pha-4, but not of daf-16 suppresses increased longevity by wwp-1 overexpression. Mutations in iron sulphur component of complex III, isp-1, increases longevity by reducing mitochondrial function. wwp-1 RNAi does not suppress the extended lifespan of isp-1 mutants and has only minor suppressive effects on lifespan of another mitochondrial mutant, clk-1, and in cyc-1 RNAi treated worms. RNAi depletion of wwp-1 has no effect on long lifespan of daf-2 mutants [19553937]. | Nematode |
| wah-1 | Worm AIF (apoptosis inducing factor) Homolog | wah-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. RNAi against wah-1 started after the animal reaches the late L4 stage extends mean lifespan by 7-8% [22103665]. | Nematode |
| wip-1 | Wiskott-Aldrich syndrome protein (WASP)-Interacting Protein and gene assignment | RNA interference decreased median lifespan by 33% in daf-2 mutants. | Nematode |
| wdr-23 | WD Repeat protein 23 | RNA interference of wdr-23 in adulthood extends mean lifespan by 24% [17411345]. | Nematode |
| his-69 | WBGene00001943 | his-69 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| wts-1 | WarTS (Drosophila) protein kinase homolog 1 | RNA interference of wts-1 in adulthood extends mean lifespan by 21% [17411345]. | Nematode |
| vit-1 | Vitellogenin-1 | vit-1 RNAi animals have a mean lifespan that 103.3% of controls, but not significant different. vit-1 is differentially expressed in daf-16 and daf-2 RNAi animals [12845331]. | Nematode |
| vit-5 | VITellogenin structural genes (yolk protein genes) 5 | RNA interference against vit-5 extends mean lifespan by 10-22%. vit-5 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331]. RNAi knockdown of vit-5 starting at hatching or only during the adulthood significantly extends lifespan of wild-type, but does not alter, or even shortens the lifespan of eat-2 mutants [22810224]. | Nematode |
| vit-2 | VITellogenin structural genes (yolk protein genes) | vit-2 RNA interference extends mean lifespan by 21-24%. vit-2 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331].
vit-2 functions in germ-line development by regulating the abundance of native versus oxidized LDL-like lipoproteins [11408580]. | Nematode |
| vig-1 | VIG (Drosophila Vasa Intronic Gene) ortholog | vig-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| vab-1 | Variable ABnormal morphology | vab-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| vang-1 | VANG (Van Gogh/Strabismus planar polarity protein) homolog) | Loss-of-function of VANG-1 (the only C. elegans orthoholog of the conserved PCP component Strabismus/Van Gogh) via mutant alleles (at 25, 20 and 18 degree Celsius) or RNAi cause an increase of mean lifespan up to 40% and 27 to 20%, respectively. Longevity phenotype of vang-1 loss-of-function animals is associated with enhanced resistance to thermal and oxidative stress, decreased lipofuscin accumulation and lowerd ROS accumulation as well as reduced brood size, decreased ovulation rate and prolonged reproductive span. The germline rather than somatic tissues, such as intestine or neurons ,appear to be the primary site of vang-1 function. Lifespan extension via vang-1 mutation depends on DAF-2 and DAF-16 as well as SKN-1. | Nematode |
