| ZDS2 | Zillion Different Screens 2 | Deletion of ZDS2 decreases replicative lifespan by about 20% [10662670].
ZDS2 null mutation decreases rDNA silencing five-fold, increases silencing at a mutant HMR that lacks the Rap1-binding site in the HNR-E silencer three-fold, and has no effect on telomeric silencing. ZDS2 deletion decreases rDNA silencing, increases rDNA recombination, and increases level of phosphorylated Sir3 [10662670].
| Budding yeast |
| ZDS1 | Zillion Different Screens 1 | Deletion of ZDS1 increases replicative lifespan by 37% in a SIR3-dependent manner [10662670].
Null mutation in ZDS1 causes 100-fold decrease in telomeric silencing, a nine-fold increase in rDNA silencing, reduces rDNA recombination, and decreases Sir3 phosphorylation [10662670]. | Budding yeast |
| ZTA1 | Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity | Deletion of ZTA1 increases replicative lifespan by 15% in the alpha strain and decreased by 10% in the a strain [18340043]. Although ZTA1 was identified as a potential long-lived mutant strain in a bar-code screen, deletion of ZTA1 does not significantly affect chronological lifespan under starvation/extreme DR [20657825]. | Budding yeast |
| UTH1 | yoUTH 1 | Mutation in UTH1 increases replicative lifespan by approximately 15% [7859289].
UTH1 mutant has enhanced stress resistance to cold stress [7859289], heat shock [10870102], starvation [7859289], hydrogen peroxide, but is sensitive to paraquat and oxygen [9799359]. | Budding yeast |
| YVH1 | Yeast vaccinia virus VH1 Homolog 1 | Deletion of YVH1 increases replicative lifespan by 50% in the alpha strain [18340043]. | Budding yeast |
| YUH1 | Yeast Ubiquitin Hydrolase 1 | Deletion of YUH1 decreases replicative lifespan decreased 30% in the alpha strain [18340043]. | Budding yeast |
| YPT7 | Yeast Protein Two 7 | YPT7 deletion decreases replicative lifespan by 15% in the alpha strain [18340043]. Deletion of YPT7 cancels out replicative lifespan extension of 0.5% glucose restriction and results under DR also into a shorter replicative lifespan than under AL [18690010]. | Budding yeast |
| YPT6 | Yeast Protein Two 6 | Deletion of YPT6 increases replicative lifespan by 20% [19030232]. YPT6 deletion increases replicative lifespan by 30% in the alpha strain and by 10% in the a strain [18340043]. | Budding yeast |
| YPT32 | Yeast Protein Two 32 | Deletion increases mean chronological lifespan by 13 - 45% (13, 17, 45) in diploid cells [21447998]. | Budding yeast |
| YPK1 | Yeast Protein Kinase 1 | Deletion of YPK1 decreases replicative lifespan by 20% in the alpha strain [18340043]. | Budding yeast |
| YPC1 | Yeast Phyto-Ceramidase 1 | Deletion of YPC1 decreases replicative lifespan by 15% in the alpha strain [19030232]. | Budding yeast |
| YOS9 | Yeast OS-9 homolog | Deletion of YOS9 decreases replicative lifespan by 10% in the alpha strain [19030232]. | Budding yeast |
| YOR1 | Yeast Oligomycin Resistance 1 | Deletion of YOR1 increases mean chronological lifespan by 21 - 25% (21, 24, 25) in diploid cells [21447998]. | Budding yeast |
| YME1 | Yeast Mitochondrial Escape 1 | Deletion of YME1 decreases chronological lifespan by 50% [17492370] as well as replicative lifespan by 45% in the alpha strain [18340043]. | Budding yeast |
| YHC3 | Yeast Homolog of human Cln3 | YHC3 deletion decreases 10-20% shortened lifespan [16435200]. | Budding yeast |
| YHB4 | Yeast HemogloBin-like protein 4 | sfa1;yhb1 double mutant cancels out the ability of moderate DR to extend replicative lifespan, but not chronological lifespan. Indicating that NO homeostasis during DR-induced replicative lifespan extension is crucial. Deleting YHB1 partially abolished DR-induced replicative lifespan extension, whereas deleting SFA1 alone had no effect. Yhb1 and Sfa1 may play redundant roles [21584246]. | Budding yeast |
| YFH1 | Yeast Frataxin Homolog 1 | Deletion of YFH1 decreases replicative lifespan by 50% [15130665]. | Budding yeast |
| YDC1 | Yeast DihydroCeramidase 1 | Overexpression of YDC1 decreases chronological lifespan by 40% [19059240] | Budding yeast |
| WHI3 | WHIskey 3 | Deletion of WHI3 decreases replicative lifespan by 25% in the a strain [18340043] and decreases chronological lifespan [21447998 ] | Budding yeast |
| VMA21 | VMA21 vacuolar H+-ATPase homolog | Replicative lifespan decreased by 60% in the alpha strain | Budding yeast |
| VMS1 | VCP/Cdc48-associated Mitochondrial Stress-responsive 1 | Deletion of VMS1 decreases replicative lifespan by 25% in the alpha strain [19030232]. | Budding yeast |
| VAC14 | VACuole morphology and inheritance mutant 14 | VAC14 mutants have a single vacuole and shortened lifespan on normal media [16293764]. | Budding yeast |
| VPS8 | Vacuolar Protein Sorting 8 | Lack of VPS8 reduces lifespan under starvation conditions to a level similiar to that of wild-type cells incubated in synthetic complete medium and therefore blocked the lifespan-extending effect of DR [20657825]. | Budding yeast |
| VPS51 | Vacuolar Protein Sorting 51 | Deletion of VPS51 increases mean chronological lifespan by 6 - 10% (6, 7, 8, 9, 10) in diploid cells [21447998]. | Budding yeast |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) | Replicative lifespan decreased by 40% in the alpha strain | Budding yeast |
