| XRCC1 | X-ray repair complementing defective repair in Chinese hamster cells 1 | XRCC1 was found to be associated with longevity [16518718]. | Human |
| wwp-1 | WW domain Protein (E3 ubiquitin ligase) 1 | RNA interference of wwp-1 decreases median lifespan by 9% in wild-type animals and 24% in daf-2 mutants [18006689]. Loss of wwp-1 function by RNAi or mutation reduces lifespan at 25 degree Celsius, but not 20 degree Celsius. wwp-1 overexpression extends lifespan by up to 20%. Reduced levels of wwp-1 completely suppress the extended longevity of eat-2 mutants. Lifespan of wwp-1 mutants across entire food concentration range by bacterial dilution in liquid culture or on solid plates does not noticeable change. There is no difference in wwp-1 mRNA levels under AL and DR. RNAi reduction of pha-4, but not of daf-16 suppresses increased longevity by wwp-1 overexpression. Mutations in iron sulphur component of complex III, isp-1, increases longevity by reducing mitochondrial function. wwp-1 RNAi does not suppress the extended lifespan of isp-1 mutants and has only minor suppressive effects on lifespan of another mitochondrial mutant, clk-1, and in cyc-1 RNAi treated worms. RNAi depletion of wwp-1 has no effect on long lifespan of daf-2 mutants [19553937]. | Nematode |
| WWOX | WW domain containing oxidoreductase | WWOX was found to be associated with longevity [22279548]. WWOX was found to be associated with longevity [24244950]. | Human |
| WRKY6 | WRKY transcription factor 6 | Deletion of the WRKY6 promoter results in defects in root and leaf cell senescence [11722756].
WRKY6 is a transcription factor involved in controlling processes related to senescence and pathogen defence [11722756] and is a positive regulator of PR1 expression [12000796]. WRKY6 is strongly expressed during senescence [11722756]. | — |
| — | Wortmannin | Treatment of Drosophila imago with 0.5 micromolar wortmannin increases median (by 5%) and maximum (by 39%) lifespan in males (p < 0.001), but the lifespan differences in females were statistical insignificant (p > 0.05) [22661237].
Low dose of wortmannin (5 microM) slightly increase the median and maximum lifespan [20017609]. | — |
| wah-1 | Worm AIF (apoptosis inducing factor) Homolog | wah-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. RNAi against wah-1 started after the animal reaches the late L4 stage extends mean lifespan by 7-8% [22103665]. | Nematode |
| wip-1 | Wiskott-Aldrich syndrome protein (WASP)-Interacting Protein and gene assignment | RNA interference decreased median lifespan by 33% in daf-2 mutants. | Nematode |
| WHI3 | WHIskey 3 | Deletion of WHI3 decreases replicative lifespan by 25% in the a strain [18340043] and decreases chronological lifespan [21447998 ] | Budding yeast |
| WRN | Werner syndrome, RecQ helicase-like | Mutation in WRN causes Werner Syndrome which characteristics includes prematurely aged facies, scleroderma-like skin changes, cataracts, arteriosclerosis, subcutaneous calcification, and diabetes mellitus [McKusick et al. 1963; 5327241]. Inheritance is autosomal recessive and malignancy is frequent. THe frequency is 3 per million individuals in Japan [7460386].
Cells from a Werner heterozygote exit the cell cycle at a faster rate than do normal cells [8265666]. Loss of WRN promoter aberrant mitotic recombination [11316787].
The single nucleotide polymorphism rs1800392 in WRN has been associated with exceptional longevity in a plethora of genetic signatures [22279548]. WRN was found to be associated with longevity [10069711; 20855428; 20855428; 20855428 ;17903295; 22406557; 16405962; 16405962; 16405962; 20855428; 20855428; 20855428; 22279548]. WRN was found to be associated with longevity [24244950]. | Human |
| wdr-23 | WD Repeat protein 23 | RNA interference of wdr-23 in adulthood extends mean lifespan by 24% [17411345]. | Nematode |
| WDR72 | WD repeat domain 72 | WDR72 was found to be associated with longevity [22279548]. | Human |
| his-69 | WBGene00001943 | his-69 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| wts-1 | WarTS (Drosophila) protein kinase homolog 1 | RNA interference of wts-1 in adulthood extends mean lifespan by 21% [17411345]. | Nematode |
| VWA5A | von Willebrand factor A domain containing 5A | VWA5A was found to be associated with longevity [21782286]. | Human |
| VMA21 | VMA21 vacuolar H+-ATPase homolog | Replicative lifespan decreased by 60% in the alpha strain | Budding yeast |
| vit-1 | Vitellogenin-1 | vit-1 RNAi animals have a mean lifespan that 103.3% of controls, but not significant different. vit-1 is differentially expressed in daf-16 and daf-2 RNAi animals [12845331]. | Nematode |
| vit-5 | VITellogenin structural genes (yolk protein genes) 5 | RNA interference against vit-5 extends mean lifespan by 10-22%. vit-5 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331]. RNAi knockdown of vit-5 starting at hatching or only during the adulthood significantly extends lifespan of wild-type, but does not alter, or even shortens the lifespan of eat-2 mutants [22810224]. | Nematode |
| vit-2 | VITellogenin structural genes (yolk protein genes) | vit-2 RNA interference extends mean lifespan by 21-24%. vit-2 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331].
vit-2 functions in germ-line development by regulating the abundance of native versus oxidized LDL-like lipoproteins [11408580]. | Nematode |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | VDR was found to be associated with longevity [21051524]. VDR was not found to be associated with longevity [20407924]. VDR was found to be associated with longevity [20407924]. | Human |
| Vitamin D receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | Vitamin D receptor was not found to be associated with longevity [21051524]. | Human |
| vig-1 | VIG (Drosophila Vasa Intronic Gene) ortholog | vig-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| VMS1 | VCP/Cdc48-associated Mitochondrial Stress-responsive 1 | Deletion of VMS1 decreases replicative lifespan by 25% in the alpha strain [19030232]. | Budding yeast |
| VASH1 | vasohibin 1 | VASH1 was found to be associated with longevity [22279548]. | Human |
| Vegf | Vascular endothelial growth factor A | Vegf exhibits rhythmic expression in the liver [17360649]. Vegf expression is affected by the circadian organization of molecular clockwork. Levels of Vegf mRNA fluctuate in a circadian fashion. Period2 and Cryptochrome inhibit the Vegf promoter [14612524]. | House mouse |
| VEGFA | vascular endothelial growth factor A | VEGFA was found to be associated with longevity [17574707]. VEGFA was not found to be associated with longevity [17574707]. | Human |
