| YPC1 | Yeast Phyto-Ceramidase 1 | Deletion of YPC1 decreases replicative lifespan by 15% in the alpha strain [19030232]. | Budding yeast |
| YOS9 | Yeast OS-9 homolog | Deletion of YOS9 decreases replicative lifespan by 10% in the alpha strain [19030232]. | Budding yeast |
| YOR1 | Yeast Oligomycin Resistance 1 | Deletion of YOR1 increases mean chronological lifespan by 21 - 25% (21, 24, 25) in diploid cells [21447998]. | Budding yeast |
| ndc-80 | Yeast NDC (nuclear division cycle) homolog) | ndc-80 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| YME1 | Yeast Mitochondrial Escape 1 | Deletion of YME1 decreases chronological lifespan by 50% [17492370] as well as replicative lifespan by 45% in the alpha strain [18340043]. | Budding yeast |
| mcm-2 | yeast MCM (licensing factor) related | RNA interference in adulthood resulted in a 15% mean lifespan extension. | Nematode |
| YHC3 | Yeast Homolog of human Cln3 | YHC3 deletion decreases 10-20% shortened lifespan [16435200]. | Budding yeast |
| YHB4 | Yeast HemogloBin-like protein 4 | sfa1;yhb1 double mutant cancels out the ability of moderate DR to extend replicative lifespan, but not chronological lifespan. Indicating that NO homeostasis during DR-induced replicative lifespan extension is crucial. Deleting YHB1 partially abolished DR-induced replicative lifespan extension, whereas deleting SFA1 alone had no effect. Yhb1 and Sfa1 may play redundant roles [21584246]. | Budding yeast |
| YFH1 | Yeast Frataxin Homolog 1 | Deletion of YFH1 decreases replicative lifespan by 50% [15130665]. | Budding yeast |
| F43G9.5 | yeast Enhancer of DeCapping homolog | F43G9.5 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| YDC1 | Yeast DihydroCeramidase 1 | Overexpression of YDC1 decreases chronological lifespan by 40% [19059240] | Budding yeast |
| bub-3 | yeast BUB homolog | RNAi against bub-3 increases mean and maximum lifespan by 6-7% and 7%, respectively [18059442]. | Nematode |
| Y77E11A.7 | Y77E11A.7b | RNA interference decreased median lifespan by 24% in wild type animals, 40% in a daf-2 background and 13% in daf-2/daf-16 double mutants. | Nematode |
| Y42G9A.4 | Y42G9A.4b | RNA interference decreased median lifespan by 14% in wild type animals and 33% in daf-2 mutants. | Nematode |
| YBX2 | Y box binding protein 2 | — | Human |
| xrn-1 | XRN (mouse/S. cerevisiae) ribonuclease related | xrn-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | XKR6 was found to be associated with longevity [22279548]. | Human |
| XPA | Xeroderma pigmentosum, complementation group A | Mutant mice exhibit symptoms of premature ageing, including reduced lifespan, osteoporosis and kyphosis, osteosclerosis, early greying, cachexia, and infertility. | House mouse |
| XDH | xanthine dehydrogenase | XDH was found to be associated with longevity [22406557; 22279548]. | Human |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | The single-nucleotide polymorphism in rs132793 in XRCC6 has significant effect on telomere length, but it is not associated with longevity [21972126]. | Human |
| Xrcc6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | XRCC5 and XRCC6 double knockout mice show decreased lifespan and signs of premature ageing without increase cancer incidence. | House mouse |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | XRCC5 was found to be associated with longevity [22406557; 16518718]. | Human |
| Xrcc5 | X-ray repair complementing defective repair in Chinese hamster cells 5 | Deletion results in signs of premature ageing such as osteopenia, atrophic skin, hepatocellular degeneration, and age specific mortality. | House mouse |
| XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 | XRCC4 was found to be associated with longevity [16518718]. | Human |
| XRCC3 | X-ray repair complementing defective repair in Chinese hamster cells 3 | XRCC3 was found to be associated with longevity [16518718]. | Human |
