| sir-2.4 | yeast SIR related 2.4 | RNA interference against sir-2.4 or overexpression of SIR-2.4 do not change the mean or maximum lifespan. Neither sir-2.4 RNAi nor SIR-2.4 overexpression affects the increased lifespan of daf-2(e1370) mutants [Tishkoff et al. 2012]. | Nematode |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | The single-nucleotide polymorphism in rs132793 in XRCC6 has significant effect on telomere length, but it is not associated with longevity [21972126]. | Human |
| vit-1 | Vitellogenin-1 | vit-1 RNAi animals have a mean lifespan that 103.3% of controls, but not significant different. vit-1 is differentially expressed in daf-16 and daf-2 RNAi animals [12845331]. | Nematode |
| Vitamin D receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | Vitamin D receptor was not found to be associated with longevity [21051524]. | Human |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | VDR was found to be associated with longevity [21051524]. VDR was not found to be associated with longevity [20407924]. VDR was found to be associated with longevity [20407924]. | Human |
| VEGFA | vascular endothelial growth factor A | VEGFA was found to be associated with longevity [17574707]. VEGFA was not found to be associated with longevity [17574707]. | Human |
| VPS36 | Vacuolar Protein Sortin 36 | VPS36 deletion mutants have a chronological lifespan as long as wild type BY4741. Thus, Vps36 is not necessary for the starvation/extreme DR-dependent lifespan extension [20657825]. | Budding yeast |
| HRAS1 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | HRAS1 was found to be associated with longevity [19367319]. HRAS1 was not found to be associated with longevity [19367319]. | Human |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | AKT3 was not found to be associated with longevity [19489743]. | Human |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | AKT2 was not found to be associated with longevity [19489743]. | Human |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | AKT1 was found to be associated with longevity [19489743]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was not found to be associated with longevity [22929028]. | Human |
| UGA4 | Utilization of GAba 4 | Deletion of UGA4 does not effect replicative lifespan [21371425]. | Budding yeast |
| UGA2 | Utilization of GAba 2 | Deletion of UGA2 does not affect replicative lifespan [21371425]. | Budding yeast |
| ucp-4 | UnCoupling Protein (mitochondrial substrate carrier) family member (ucp-4) | Overexpression reduces mean lifespan by 5%, has no significant effect on median lifespan, and slighlty increases maximum lifespan by 12% [22737090]. | Nematode |
| unc-24 | UNCordinated 24 | Mutations in unc-24 have no significant effect on lifespan [9789046] and unc-24(e138) fails to extend male lifespan [10747056].
unc-24 mutant is uncoordinated and displays irregular movement [4366476; 8667025]. | Nematode |
| unc-78 | UNCoordinated 78 | Mutation in unc-78 has no effect on lifespan [9789046].
unc-78 mutants move slowly [7190524]. | Nematode |
| unc-6 | UNCoordinated 6 | Mutation in unc-6 has no effect on lifespan [9789046].
unc-6 mutants are uncoordinated [4366476]. | Nematode |
| unc-54 | UNCoordinated 54 | Mutation in unc-54 has no effect on lifespan [9789046].
unc-54 mutants are paralyzed [4366476]. | Nematode |
| unc-52 | UNCoordinated 52 | RNA interference of unc-52 in adulthood extends mean lifespan by 11% [17411345]. RNAi knockdown of unc-52 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. UNC-52 levels are elevated in eat-2 mutants. Increased content of UNC-52 is, at least partially, required for lifespan-extension by DR [22810224]. | Nematode |
| unc-49 | UNCoordinated 49 | The unc-49(e382) allele has no significant effect on lifespan [9789046].
unc-49 mutants are uncoordinated [4366476]. | Nematode |
| unc-47 | UNCoordinated 47 | The unc-47(e367) allele has no significant effect on lifespan [9789046].
unc-47 mutants are uncoordinated [4366476]. | Nematode |
| unc-46 | UNCoordinated 46 | unc-46(e177) allele has no significant effect on lifespan [9789046].
unc-46 mutants are uncoordinated [4366476]. | Nematode |
| unc-30 | UNCoordinated 30 | Mutations in unc-30 have no significant effect on lifespan [9789046].
unc-30 mutants are uncoordinated [4366476]. | Nematode |
| unc-25 | UNCoordinated 25 | Mutations in unc-25 have no effect on lifespan [9789046].
unc-25 mutants are defective for foraging, locomotion, and defecation [8332190] as well as uncoordinated [4366476]. | Nematode |
| unc-2 | UNCoordinated 2 | Loss of function in unc-2 has no effect on lifespan [9789046].
unc-2 mutant is uncoordinated [4366476] and its rate of pharyngeal pumping is reduced [8325482]. | Nematode |
