| bub-3 | yeast BUB homolog | RNAi against bub-3 increases mean and maximum lifespan by 6-7% and 7%, respectively [18059442]. | Nematode |
| wah-1 | Worm AIF (apoptosis inducing factor) Homolog | wah-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. RNAi against wah-1 started after the animal reaches the late L4 stage extends mean lifespan by 7-8% [22103665]. | Nematode |
| wdr-23 | WD Repeat protein 23 | RNA interference of wdr-23 in adulthood extends mean lifespan by 24% [17411345]. | Nematode |
| wts-1 | WarTS (Drosophila) protein kinase homolog 1 | RNA interference of wts-1 in adulthood extends mean lifespan by 21% [17411345]. | Nematode |
| vit-5 | VITellogenin structural genes (yolk protein genes) 5 | RNA interference against vit-5 extends mean lifespan by 10-22%. vit-5 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331]. RNAi knockdown of vit-5 starting at hatching or only during the adulthood significantly extends lifespan of wild-type, but does not alter, or even shortens the lifespan of eat-2 mutants [22810224]. | Nematode |
| vit-2 | VITellogenin structural genes (yolk protein genes) | vit-2 RNA interference extends mean lifespan by 21-24%. vit-2 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331].
vit-2 functions in germ-line development by regulating the abundance of native versus oxidized LDL-like lipoproteins [11408580]. | Nematode |
| unc-52 | UNCoordinated 52 | RNA interference of unc-52 in adulthood extends mean lifespan by 11% [17411345]. RNAi knockdown of unc-52 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. UNC-52 levels are elevated in eat-2 mutants. Increased content of UNC-52 is, at least partially, required for lifespan-extension by DR [22810224]. | Nematode |
| unc-17 | UNCoordinated 17 | unc-17 encodes acteylcholine transporter which is expressed in motor [18041778] and inter-neurons and is downregulated in space. Mutation of unc-17 extends lifespan on NGM agar covered with killed or live bacteria. nc-17(CB933) extends mean, 75%ile, and maximum lifespan by 31-79%, 68-89%, and 68-79%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of daf-16, but not skn-1. eat-2 RNAi further enhances the extension of lifespan by mutations of unc-17 [22768380].
Mutation and RNAi of unc-17 suppresses pheromone-induced dauer formation [22768380].
| Nematode |
| unc-26 | UNCoordinated | Mutations in unc-26 extend lifespan by 30-50%. Lifespan extension is proposed to be similar to DR [9789046].
unc-26 mutants are uncoordinated, slow and have defects in pharyngeal pumping [4366476; 8462849]. | Nematode |
| unc-32 | UNCoordinated | unc-32 mutation extends male lifespan by about 170%, but has no effect on hermaphrodite lifespan [10747056].
unc-31 mutants are uncoordinated [4366476]. | Nematode |
| unc-4 | UNCoordinated | Lifespan of unc-4(e120) males is extended relative to hermaphrodites approximately 2-fold [10747056]. Mutation in unc-4 has no significant effect on hermaphrodite lifespan [9789046].
unc-4 mutants are uncoordinated [4366476]. | Nematode |
| unc-13 | UNCoordinated | Mutation in unc-13 results in a 150% life-extension in males, but has no effect on hermaphrodite lifespan [10747056]. | Nematode |
| unc-64 | UNCoordinated | Mutations in unc-64 result in constitutive dauer formation and increase lifespan, which is suppressed by mutations in daf-16 [10377425]. unc-64 mutation increases mean and maximum lifespan [16280150]. unc-64 mutation increased lifespan of hermaphrodites by approximately 70% and those of males by 150% [10377425; 4366476; 10747056].
unc-64 mutants are uncoordinated [4366476]. | Nematode |
| unc-76 | UNCoordinated | unc-76(e911) allele extends male lifespan by about 50%, but has no effect on hermaphrodite lifespan [10747056].
unc-76 mutants are uncoordinated [4366476]. | Nematode |
| ubh-4 | UBiquitin C-terminal Hydrolase (family 1) | RNAi of ubh-4 starting at L1 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. | Nematode |
| ucr-1 | Ubiquinol-Cytochrome c oxidoReductase complex | RNAi against ucr-1 increases mean lifespan by 20% [17608836]. ucr-1 RNAi started after the animal reached the late L4 stage increase mean lifespan by 8-14% [22103665]. | Nematode |
| tub-1 | TUBby-related | Mutation of tub-1 (alleles nr2004 and nr2044) leads to 20-25% life-extension dependent on daf-16 [16054097].
tub-1 mutation promotes increased fat accumulation [16054097]. | Nematode |
| C47D12.2 | TRRAP-like (transcription/transformation domain-associated protein) | C47D12.2 RNAi in the adulthood extends mean and maximum lifespan by 6 and 9% [23144747]. | Nematode |
| trim-9 | TRIpartite Motif-containing protein homolog 9 | RNA interference of trim-9 extends lifespan [15998808]. | Nematode |
| C09B7.2 | transposase | RNA interference of C09B7.2 extends lifespan [15998808]. | Nematode |
| tag-322 | Temporarily Assigned Gene name | tag-322 RNAi increases mean and maximum lifespan by 18 and 12%, respectively [19293945]. | Nematode |
| tdp-1 | TAR DNA-binding Protein homolog 1 | tdp-1(ok803) mutation increases mean and maximum lifespan at 20 degree Celsius but not at 25 degree Celsius. tdp-1(ok803) reduce the lifespan of daf-2(e1370) mutants, but does not does not reduces the lifespan of daf-16(mu86) mutants. RNAi against tdp-1 reduces lifepsna of daf-2(e1370) mutants. tdp-1 overexpression strains have a reduced lifespan at 20 and 25 degree Celsius [Vaccaro et al. 2012]. | Nematode |
| sid-2 | Systemic RNA Interference Defective 2 | RNA interference of sid-2 extends lifespan [15998808]. | Nematode |
| rsr-1 | SR protein related 1 | rsr-1 RNAi in the adulthood extends the mean lifespan by 6% without an effect on maximum lifespan [23144747]. | Nematode |
| spt-4 | SPT transcription factor family | RNAi of spt-4 starting at L1 extends mean, 75%ile and median lifespan by 4, 8 and 8% [15998808]. | Nematode |
