| GTR1 | GTp binding protein Resemblance 1 | GTR1 deletion decreases mean and maximum replicative lifespan under AL by 36 and 51%, respectively, and cancels out the lifespan extending effect of DR [22912585]. | Budding yeast |
| DAP2 | Dipeptidyl AminoPeptidase 2 | DAP2 deletion decreases mean and maximum replicative lifespan under AL by 19 and 36%, respectively, and cancels out the lifespan extending effect of moderate DR [22912585]. | Budding yeast |
| CCR4 | Carbon Catabolite Repression 4 | Deletion of CCR4 increases mean chronological lifespan by 20 - 41% (20, 33, 41) in diploid cells [21447998]. In W303R CCR4 deletion shortens replicative lifespan by approximately 80% and results in temperature sensitivity that is suppressed by SSD1-V. SSD1-V partially suppresses the short-lifespan of ccr4 mutant. CCR4 mutation is synthetically lethal in combination with deletion of MPT5 in the absence of SSD1-V [11805047]. | Budding yeast |
| ACO1 | ACOnitase 1 | Deletion of ACO1 decreases mean chronological lifespan by 42 - 56% in diploid cells [21447998]. | Budding yeast |
| KES1 | KrE11-1 Suppressor | Deletion of OSH4 decreases mean replicative lifespan by 18% [Xia et al., unpublished]. | Budding yeast |
| GTS1 | Glycine Threonine Serine repeat protein 1 | Deletion or overexpression of GTS1 shortens replicative lifespan significantly and slightly, respectively (wt:26, Delta:16 and OE:24) [8573138]. | Budding yeast |
| TSA1 | Thiol-Specific Antioxidant 1 | A gain-of-function allele of peroxiredoxin (thioredoxin peroxidase, Tsa1) causes a dominant oxidative stress-resistance and robust premature aging phenotype with reduced mean lifespan. These effect is not provoked by altered Tsa1 levels, nor can it be stimulated by deletion, haploinssufficiency or overexpression of wild-type allele [20729566]. Disruption of TSA1 shortens chronological lifespan [15129730]. Replicative lifespan extension by DR in sir2;fob1 double mutant is reduced by TSA1 deletion mutant. Wild-type cells require TSA1 to fully extend lifespan. Mutation in CDC35 (adenylate cyclase), a genetic mimetic of DR, is dependent on TSA1 to extend lifespan [21884982]. | Budding yeast |
| ATG7 | Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation | ATG7 deletion reduces chronological lifespan by 70% [19302372]. | Budding yeast |
| ATG1 | AuTophaGy related 11 | ATG1 deletion reduces chronological lifespan by 70% [19302372]. Deletion of ATG1 reduces replicative lifespan by 20% in the alpha strain [18340043]. | Budding yeast |
| ZDS2 | Zillion Different Screens 2 | Deletion of ZDS2 decreases replicative lifespan by about 20% [10662670].
ZDS2 null mutation decreases rDNA silencing five-fold, increases silencing at a mutant HMR that lacks the Rap1-binding site in the HNR-E silencer three-fold, and has no effect on telomeric silencing. ZDS2 deletion decreases rDNA silencing, increases rDNA recombination, and increases level of phosphorylated Sir3 [10662670].
| Budding yeast |
| YUH1 | Yeast Ubiquitin Hydrolase 1 | Deletion of YUH1 decreases replicative lifespan decreased 30% in the alpha strain [18340043]. | Budding yeast |
| YPT7 | Yeast Protein Two 7 | YPT7 deletion decreases replicative lifespan by 15% in the alpha strain [18340043]. Deletion of YPT7 cancels out replicative lifespan extension of 0.5% glucose restriction and results under DR also into a shorter replicative lifespan than under AL [18690010]. | Budding yeast |
| YPR011C | — | Deletion of YPR011V decreases replicative lifespan by 20% in the a strain [18340043]. | Budding yeast |
| TAE2 | Translation Associated Element 2 | TAE2 deletion decreases replicative lifespan by 30% in the a strain [18340043]. | Budding yeast |
| YPK1 | Yeast Protein Kinase 1 | Deletion of YPK1 decreases replicative lifespan by 20% in the alpha strain [18340043]. | Budding yeast |
| YPC1 | Yeast Phyto-Ceramidase 1 | Deletion of YPC1 decreases replicative lifespan by 15% in the alpha strain [19030232]. | Budding yeast |
| YOS9 | Yeast OS-9 homolog | Deletion of YOS9 decreases replicative lifespan by 10% in the alpha strain [19030232]. | Budding yeast |
| YNR066C | — | Deletion of YNR066C decrease replicative lifespan by 50% in the alpha strain [19030232]. | Budding yeast |
| YMR166C | — | Deletion of YMR166C decreases replicative lifespan by 20% in the alpha strain [18340043]. | Budding yeast |
| YME1 | Yeast Mitochondrial Escape 1 | Deletion of YME1 decreases chronological lifespan by 50% [17492370] as well as replicative lifespan by 45% in the alpha strain [18340043]. | Budding yeast |
| YLR460C | — | Deletion of YLR460C decreases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
| GMC2 | Grand Meiotic recombination Cluster 2 | Deletion of GMC2 decreases replicative lifespan by 50% in the alpha strain [19030232]. | Budding yeast |
| DIF1 | Damage-regulated Import Facilitator 1 | Deletion of DIF1 decreases replicative lifespan by 20% in the alpha strain [19030232]. | Budding yeast |
| TDA5 | Topoisomerase I Damage Affected 5 | Deletion of TDA5 decreases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
| YKL069W | — | Deletion of YKL069W increases sensitivity to oxidative stress and decreases replicative lifespan [19049972]. | Budding yeast |
