| YDR248C | — | Deletion of YDR248C increases replicative lifespan by 20% in the alpha strain [19030232]. | Budding yeast |
| YDC1 | Yeast DihydroCeramidase 1 | Overexpression of YDC1 decreases chronological lifespan by 40% [19059240] | Budding yeast |
| VHS1 | Viable in a Hal3 Sit4 background 1 | Deletion of VHS1 increases replicative lifespan [16293764]. VHS1 deletion increases replicative lifespan by 60% in the alpha strain [19030232]. | Budding yeast |
| TOS8 | Target Of Sbf 8 | Deletion of TOS8 increases replicative lifespan increased by 35% in the alpha strain [18340043]. | Budding yeast |
| TMA19 | Translation Machinery Associated 19 | Deletion of TMA19 increases replicative lifespan by 16% (P<0.02) [16806052]. TMA19 deletion increases replicative lifespan by 25-30% in the alpha and a strains [19030232].
| Budding yeast |
| TIF4631 | Translation Initiation Factor 4631 | Deletion of TIF4631 increases replicative lifespan by 20% in the alpha and a strains [18340043].
TIF4631 increases replicative lifespan by 10-20% in the alpha and a strains [19030232]. | Budding yeast |
| TIF1 | Translation Initiation Factor 1 | Deletion of TIF1 increases replicative lifespan by 20% in the alpha strain [19030232]. TIF1 deletion increases by 30% in the alpha strain and 15% in the a strain [18340043].
| Budding yeast |
| SKN1 | Suppressor of Kre Null 1 | Chronological lifespan increased by 60% for single skn1 and double ipt1-skn1 deletion [16527275]. | Budding yeast |
| SCP1 | S. cerevisiae CalPonin 1 | Increasing actin dynamics by deletion of SCP1, encoding an actin bundling protein, increases replicative lifespan by 67% as well as chronological lifespan by 88%, whereas its overexpression leads to elevuated ROS levels and reduces chronological lifespan (in KAY446 strain) [15024029]. SCP1 is related to mammalian SM22/transgelin which is induced during senescence [9570922]. | Budding yeast |
| SAM1 | S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p) | Deletion of SAM1 increases replicative lifespan by 20% in the alpha strain and 15% in the a strain [18340043]. | Budding yeast |
| RPS6A | Ribosomal Protein of the Small Subunit 6A | Deletion of RPS6A increases replicative lifespan by 30% in alpha strain [18423200; 18340043]. | Budding yeast |
| RPL9B | Ribosomal Protein of the Large subunit 9B | Deletion of RPL9B increases replicative lifespan by 30% in a strain [18423200; 18340043]. | Budding yeast |
| RPL9A | Ribosomal Protein of the Large subunit 9A | Deletion of RPL9A increases replicative lifespan by 30% in the alpha strain and 20% in a strain [18423200; 18340043] | Budding yeast |
| RPL4A | Ribosomal Protein of the Large subunit 4A | Deletion of RPL4A increases replicative lifespan by 15% in the alpha strain [18340043]. RPL4A deletion increases replicative lifespan by 20% in the alpha strain [18423200]. | Budding yeast |
| RPL37B | Ribosomal Protein of the Large subunit 37B | Deletion of RPL37B increases replicative lifespan by 35% in the alpha strain [18423200]. RPL37B deletion increases replicative lifespan by 35% in the alpha strain and 30% in a strain [19030232]. | Budding yeast |
| RPL20B | Ribosomal Protein of the Large subunit 20B | Deletion of RPL20B increases mean replicative lifespan by 35 - 50% [19030232] to 40 - 50% [18423200] in the alpha and a strains. While deletion of RPL20B non-significantly increases mean replicative lifespan by 3% in the ORF collection, it significantly by 36% the remade strain [22377630].
RPL20b deletion extends mean, median and maximum lifespan by 71, 89 and 82%, respectively [23167605].
Lifespan extension by RPL20B deletion is Hac1, Sir2 and Fob1 independent, but requires Gcn4 [18423200; 21902802]. | Budding yeast |
| RPL12B | Ribosomal Protein of the Large subunit 12B | Deletion of RPL12B increases mean replicative lifespan by 20% in the alpha strain [18423200] and by 22% in the remade strain, but increases non-significantly the mean replicative lifespan by 13% in the ORF collection [22377630]. RPL12B mutation promotes mean chronological longevity extension and heat-shock resistance but reduces acetic acid resistance under starvation/extreme DR. In DBY746 mutation of RPL12B almost doubles mean chronological lifespan in SDC medium and increases heat-shock resistance [20657825] | Budding yeast |
| PMR1 | High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease | Deletion of PMR1 increses the replicative lifespan by 40% in the alpha strain and by 15% in the a strain. Overexpression of PMR1 extends the lifespan [21918615]. | Budding yeast |
| PKH2 | Pkb-activating Kinase Homolog 2 | PKH2 deletion increases replicative lifespan by 20% in the alpha strain and by 15% in the a strain [18340043]. Deletion of PKH2 increases chronological lifespan by 29% [22319457] to 34% [21447998] as well as by 19 - 54% (19, 24, 29, 54) in diploid cells [21447998]. PKH2 mutation extends both replicative and chronological lifespan as well as cancels out DR-induced replicative and chronological lifespan extension [21584246]. Mean and maximum replicative lifespan on AL is extended by 38 and 69%, respectively. | Budding yeast |
| PIB1 | PhosphatidylInositol(3)-phosphate Binding 1 | Deletion of PIB1 increases replicative lifespan by 25% in the alpha strain [16293764; 19030232]. | Budding yeast |
| NMD4 | Nonsense-Mediated mRNA Decay 4 | Deletion of NMD4 increases replicative lifespan [16293764]. NMD4 deletion results in replicative lifespan increase by 25% in the alpha strain and decrease by 20% in a strain [19030232]. | Budding yeast |
| NDE1 | NADH Dehydrogenase, External 1 | Overexpression of NDE1 and NDE2 increases intracellular NAD/NADH ratio by lowering NADH concentration and increases replicative lifespan by 20-25%. This lifespan extension is non-additive 0.5% glucose restriction [14724176]. Deletion of NDE1 extends chronological lifespan [16436509]. | Budding yeast |
| LYS9 | LYSine requiring 9 | Deletion of LYS9 increases replicative lifespan [16293764]. LYS9 deletion increases replicative lifespan by 20% in the alpha strain [19030232]. | Budding yeast |
| LIN1 | LINk | Deletion of LIN1 increases replicative lifespan [16293764]. LIN1 deletion increases replicative lifespan by 40% in the alpha strain [19030232]. | Budding yeast |
| LAG1 | Ceramide synthase component | A gene deletion of LAG1 in haploid cells results in a pronounced increase (approximately 50%) in mean and in maximum replicative lifespan in the YPHDF-1A strain [8195187], but has no significant effect on lifespan in stains W303R or PSY316 (N. Bishop, G.Liszt, and L. Guarente, unpublished]. The LAG1 transcribed is preferentially expressed in young cells. LAG1 null mutant is viable and has no obvious phenotypes but shows delayed ER to Golgi transport when combined with DGT1 mutation [10198056] and is synthetical lethal with LAC1 deletion. | Budding yeast |
