Denigma

Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
    Nematode « 
  • Classifications: + -
    Positive Aging‑Suppressor «  Positive Gerontogene «  Aging‑Suppressor (2)   Gerontogene (2)  
  • Types: + -
    • symbol name observation species
    old-1 Overexpression Longevity Determinant Overexpression of old-1 in transgenic animals increases mean and maximum lifespan by 40-100% (average 65%) and 97%, respectively. old-1 overexpression of increases stress resistance (to heat by 20% and ultraviolet irradiation by 33%) without altering development or fertility. Effects of old-1 on lifespan and stress resistance is under regulation of daf-16 [9768365]. old-1 mRNA levels are upregulated in response to stress and in daf-2 as well as age-1 mutant backgrounds [11591319]. old-1 expression is downregulated in daf-2 mutants [12845331]. old-1 RNAi in an rrf-3 mutant background slightly extends lifespan [12845331]. old-1 is expressed in the anterior region of the worm, in neuronal, hypodermal and pharyngeal tissues as well in the proximal region in the male gonad. Its expression is detectable in young adults and appears to increase as animals age and in response to heat, starvation, or UV irradiation. Nematode
    ins-1 INSulin related Increased dosage of ins-1 under its own promoter as well as a heat shock promoter increases lifespan by 25% and is also able to increase the lifespan of daf-2 mutants [11274053]. ins-1 RNAi increases lifespan by 20%. ins-1 is differentially transcribed in daf-16 and daf-2 animals [12845331]. Overexpression of ins-1 also causes an increase in dauer formation and can enhance the dauer formation of daf-2 mutants [11274053]. Nematode
    • 2 factors
    Factors are an extension of GenAge and GenDR.

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