Denigma: Factor

IDP3

Symbol: IDP3
Name: Isocitrate Dehydrogenase, NADP-specific 3
Entrez gene ID: 855723
Ensembl gene ID: YNL009W
Species: Yeast (Taxid: 4932)

Functional description:
Idp3p; Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids [Source:SGD;Acc:S000004954] [Ensembl]

Observation:

Deletion of IDP3 results in a replicative lifespan increase by 15% in the alpha strain and decrease by 20% in the a strain [18340043; 19030232].

Interventions:

IDP3 deletion -20 to +15%

Assays: Replicative Lifespan

Classification:

Aging Associated

Aging Relevance Analysis/Source:

GenAge