Symbol: GCN2 Name: General Control Nonderepressible 2 Entrez gene ID: 851877 Ensembl gene ID: YDR283C Species: Yeast (Taxid: 4932) Functional description: Gcn2p; Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control [Source:SGD;Acc:S000002691] [Ensembl] Observation: Deletion of GCN2 decreases replicative lifespan by 10% in a strain [18340043]. GCN2 deletion decreases replicative lifespan by 10-20% in both alpha and a strains [19030232]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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