Symbol: tax-6 Name: abnormal CHEmotaxis 6 Entrez gene ID: 177943 Ensembl gene ID: C02F4.2 Species: Worm (Taxid: 6239) Functional description: Protein TAX-6; abnormal CHEmotaxis family member (tax-6) [Source:RefSeq peptide;Acc:NP_001021292] [Ensembl]; tax-6 encodes an ortholog of calcineurin A that is required for inhibition and adaptation of several sensory neurons and for the normal regulation of egg-laying by serotonin; TAX-6 stimulates transcription of rcn-1, and binds RCN-1 protein if free Ca[2+] is present; in general, calcineurin positively regulates calcium-dependent signaling; tax-6 loss-of-function mutants exhibit an extended lifespan which is characterized by enhanced autophagy and dependent upon the presence of functional bec-1. [WormBase] Observation: Post-developmental RNA interference of tax-6 increases mean lifespan by 27% [17673661]. tax-6 RNAi extends lifespan [21331044]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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