Denigma

Sirt2

Symbol: Sirt2
Entrez gene ID: 42414
Ensembl gene ID: FBgn0038788
Species: Fly (Taxid: 7227)

Functional description:
NAD(+)-dependent histone deacetylase that silences gene expression; NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span. [UniProt]

Observation:

Decreased expression of Sirt2 by RNA interference causes lethality during development. Silencing in neurons shortened mean lifespan by 20% [17159295].



Interventions:
  • Sirt2 RNAi -20%

    • Assays: Organismal Lifespan
    Mean: -20

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


    • Type:
  • Gene
  • Protein coding

    References:
  • 17159295: Involvement of Drosophila Sir2-like genes in the regulation of life span.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • SIRT2 (9606)
  • SIRT2 (9598)
  • SIRT2 (9615)
  • SIRT2 (9913)
  • Sirt2 (10090)
  • Sirt2 (10116)
  • sirt2 (7955)
  • Sirt2 (7227)
  • AgaP_AGAP002943 (7165)
  • hst2 (4896)
  • HST2 (4932)
  • KLLA0F11033g (28985)
  • AGOS_AGL018C (33169)
  • GeneID:5048967 (148305)
  • NCU00523 (5141)

    • Orthologs
  • HST2 (4932)
  • HST2 (4932)
  • HST2 (4932)

    • Inparanoids
  • ENSMUSP00000072732 (10090)
  • ENSRNOP00000027384 (10116)
  • ENSMMUP00000031121 (9544)
  • ENSP00000375931 (9606)
  • YPL015C (4932)
  • SPCC132.02 (4896)



    • Edit \ Update (Admin) | Delete

    Comment on This Data Unit