Symbol: scl-1 Name: SCP-Like extracellular protein Entrez gene ID: 186053 Ensembl gene ID: F49E11.9 Species: Worm (Taxid: 6239) Functional description: Protein SCL-1; SCP-Like extracellular protein family member (scl-1) [Source:RefSeq peptide;Acc:NP_502502] [Ensembl]; scl-1 encodes a predicted secretory protein that is a member of the cysteine-rich secretory protein (CRISP) family; scl-1 activity positively regulates longevity and stress resistance; in wild-type animals, scl-1 mRNA is detected solely in eggs, while in daf-2 mutants it is detected in eggs and late adult stages; scl-1 expression appears to be under the control of the DAF-2/insulin-like signaling pathway as, in mixed-stage cultures, scl-1 mRNA levels are increased in daf-2 and age-1 mutants and undetectable in daf-16 mutants; scl-1 contains a DAF-16 consensus binding element within its predicted regulatory regions. [WormBase] Observation: Downregulation of scl-1 by RNAi reduces slightly but reproducibly lifespan as well as stress resistance, similar to the effect of mutation in daf-16. scl-1 RNAi prevents lifespan extension associated with mutation of daf-2 or age-1. scl-1 contains several DAF-16 consensus binding elements within its predicted regulatory region and is a direct target for transcriptional activation by DAF-16. scl-1 mRNA levels increase highly in daf-2 and age-1 mutation, lowly in wild-type N2 and undetectable in daf-16 mutants. [12620193]. RNAi of scl-1 causes hat shock and UV sensitivity [12620193]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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