Symbol: RAS2
Name: Ras-like protein 2
Alias: CTN5; CYR3; GLC5; TSL7
Entrez gene ID: 855625
Ensembl gene ID: YNL098C
Species: Yeast
(Taxid: 4932)
Functional description:
Ras2p; GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes [Source:SGD;Acc:S000005042] [Ensembl]
Observation:
Overexpression of RAS2 causes a 43% increase in mean and 18% increase in maximum lifespan as well as postpones the age-related increase in generation time. RAS2 deletion causes a 23% decrease in mean and a 30% decrease in maximum lifespan [8034612]. Deletion of RAS2 leads to a longer chronological lifespan [21076178]. Deletion of the RAS2 gene, which functions upstream of CYR1, doubles the mean chronological lifespan by a mechanism that requires Msn2/4 and Sod2 [12586694]. DR further extends chronological lifespan of ras2Delta [18225956].
Interventions:
RAS2 deletion
-23%
-30%
RAS2 overexpression
+43%
+18%
Assays:
Replicative Lifespan
Chronological Lifespan
Classification:
Aging-Suppressor
Negative Aging-Suppressor
Gerontogene
Positive Gerontogene
DR-Essential
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
RRAS2
(9606)
RRAS2
(9598)
RRAS2
(9615)
RRAS2
(9913)
Rras2
(10090)
Rras2
(10116)
RRAS2
(9031)
rras2
(7955)
Ras64B
(7227)
AgaP_AGAP002812
(7165)
ras-1
(6239)
ras1
(4896)
RAS2
(4932)
RAS1
(4932)
KLLA0C13387g
(28985)
AGOS_ADL262W
(33169)
GeneID:2684336
(148305)
NCU08823
(5141)
Orthologs
RIT1
(9606)
Rit2
(10116)
ras-2
(6239)
Mras
(10116)
RRAS2
(9606)
MRAS
(9606)
ras-1
(6239)
LOC699700
(9544)
Rras
(10090)
Ric
(7227)
Rras2
(10116)
Rit2
(10090)
Rit1
(10090)
RRAS
(9544)
Rit1
(10116)
ras1
(4896)
RIT2
(9544)
RRAS
(9606)
Ras64B
(7227)
MRAS
(9544)
Rras
(10116)
RIT1
(9544)
Rras2
(10090)
Mras
(10090)
RIT2
(9606)
RIT1
(9606)
Rit2
(10116)
ras-2
(6239)
Mras
(10116)
RRAS2
(9606)
MRAS
(9606)
ras-1
(6239)
LOC699700
(9544)
Rras
(10090)
Ric
(7227)
Rras2
(10116)
Rit2
(10090)
Rit1
(10090)
RRAS
(9544)
Rit1
(10116)
ras1
(4896)
RIT2
(9544)
RRAS
(9606)
Ras64B
(7227)
MRAS
(9544)
Rras
(10116)
RIT1
(9544)
RAS1
(4932)
Rras2
(10090)
Mras
(10090)
RIT2
(9606)
RIT1
(9606)
Rit2
(10116)
ras-2
(6239)
Mras
(10116)
RRAS2
(9606)
MRAS
(9606)
ras-1
(6239)
RIT1
(9544)
Rras
(10090)
Ric
(7227)
Rras2
(10116)
Rit2
(10090)
LOC699700
(9544)
Rit1
(10090)
RIT2
(9544)
Rit1
(10116)
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