Knockouts of Prop1 are dwarf (hence called the Ames dwarf mice) but live approximately 1 year longer than controls. Mean lifespan of males and females is extended by 49 and 68%, respectively [8900272]. Ames dwarf mice are small due to retarded post-natal growth with a body size of one-third upon maturation into adulthood) [10838701; 8900272] and have primary pituitary deficiency consisting of the absence of, or extreme reduction in, anterior pituitary cells which produces growth hormone, prolactin and thyroid-stimulating hormone, and consequently a deficiency in these hormones [8565826; 8900272]. Levels of IGF1 is also extreme low in Ames dwarf mice [8900272] and they maintain lower body temperature at rest and during stress, which is on average 1.6 degree Celsius lower [10497963]. df/df mice tend to be steril [14173795].

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