Symbol: POSH Name: Plenty of SH3s Alias: POSH Entrez gene ID: 36990 Ensembl gene ID: FBgn0040294 Species: Fly (Taxid: 7227) Functional description: Plenty of SH3s; Plenty of SH3s [Source:FlyBase gene name;Acc:FBgn0040294] [Ensembl]; The gene Plenty of SH3s is referred to in FlyBase by the symbol Dmel\POSH (CG4909, FBgn0040294). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process: protein localization; negative regulation of cell death; determination of adult lifespan; pole plasm oskar mRNA localization; oocyte microtubule cytoskeleton polarization; rhabdomere development. 14 alleles are reported. The phenotypes of these alleles are annotated with: eye; macrochaeta; genitalia; tarsal segment; wing; melanotic mass; wing hair. It has one annotated transcript and one annotated polypeptide. Protein features are: Neutrophil cytosol factor 2 p67phox; Src homology-3 domain; Zinc finger, C3HC4 RING-type; Zinc finger, RING-type; Zinc finger, RING-type, conserved site; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [FlyBase] Observation: Neural-specific overexpression of POSH extends the mean lifespan of adult flies by 14% at 25°C. Ectopic expression of POSH during development results in morphological abnormalities [11868902]. Interventions: Assays: Organismal Lifespan Mean: +14 Classification: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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