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Symbol: ovo Entrez gene ID: 31429 Ensembl gene ID: FBgn0003028 Species: Fly (Taxid: 7227) Functional description: Transcription factor required for female germ line maintenance and gametogenesis [Mevel-Ninio et al. 1991]; Required for the survival and differentiation of female germline cells. Plays a role in germline sex determination. Also has a somatic role regulating denticle formation and initiating cytoskeletal remodeling during epidermal differentiation. The different isoforms act antagonistically to each other having transcriptional repressor or activator activity. Binds the promoter DNA and regulates the transcription of the otu gene in a stage-specific manner. [UniProt] Observation: The dominant ovoD1 allele extends female lifespan by approximately 50%. It does not synergize or prevent life-extension caused by chico [10617470; 11292874]. ovoD1 mutants are sterile [Mevel-Ninio et al. 1991]. Interventions: Assays: Organismal Lifespan Mean: +50 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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