Denigma: Factor

BCY1

Symbol: BCY1
Name: Bypass of CYclase mutations
Entrez gene ID: 854778
Ensembl gene ID: YIL033C
Species: Yeast (Taxid: 4932)

Functional description:
Bcy1p; Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation [Source:SGD;Acc:S000001295] [Ensembl]

Observation:

Disruption in BCY1 by mutation results decreases mean and maximum replicative lifespan by 37 and 16% and is associated with increased PKA activity [8195187].

Interventions:

BCY1 deletion -37% -16%

Assays: Replicative Lifespan

Classification:

Aging-Suppressor

Negative Aging-Suppressor

References:

8195187: Cloning and characterization of LAG1, a longevity-assurance gene in yeast.

Aging Relevance Analysis/Source:

GenAge