Denigma

let-60

Symbol: let-60
Name: LEThal
Entrez gene ID: 178104
Ensembl gene ID: ZK792.6
Species: Worm (Taxid: 6239)

Functional description:
The level of let-60 controls the switch between vulval and hypodermal cell fates during C.elegans vulval induction. [UniProt]

Observation:

The let-60(n1046gf) activating mutation greatly reduces lifespan of wild-type, weakly suppresses constitutive dauer diapause in daf-2 and age-1 mutants and extends lifespan induced by mutation of daf-2 [16164423].



Interventions:
  • Activating let-60 mutation

    • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Negative Gerontogene


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • KRAS (9606)
  • KRAS (9598)
  • KRAS (9615)
  • KRAS (9913)
  • Kras (10090)
  • Kras (10116)
  • KRAS (9031)
  • kras (7955)
  • Ras85D (7227)
  • AgaP_AGAP002219 (7165)
  • let-60 (6239)

    • Note: let-60 greatly decreases lifespan and appears not to have any epistatic interactions with daf-2.

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