Denigma

Trxr-1

Symbol: Trxr-1
Name: Thioredoxin reductase-1
Alias: GSR; Glutathione reductase
Entrez gene ID: 31760
Ensembl gene ID: ZC395.6
Species: Fly (Taxid: 7227)

Functional description:
Redox regulation and oxidative defence; Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms. [UniProt]

Observation:

Overexpression of Trxr-1 (alias GSR; glutathione reductase) in transgenic flies results in increased lifespan and oxidative stress resistance, but only under hyperoxia [10506576].



Interventions:
  • Trxr-1 overexpression

    • Assays: Organismal Lifespan

    Classification:
  • Aging Associated


    • References:
  • 10506576: Overexpression of glutathione reductase extends survival in transgenic Drosophila melanogaster under hyperoxia but not normoxia.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • TXNRD2 (9606)
  • TXNRD2 (9598)
  • TXNRD2 (9615)
  • TXNRD2 (9913)
  • Txnrd2 (10090)
  • Txnrd2 (10116)
  • TXNRD2 (9031)
  • Trxr-1 (7227)
  • Trxr-2 (7227)
  • TRXR (7165)
  • trxr-2 (6239)
  • PFI1170c (5833)

    • Inparanoids
  • FBpp0071116 (7227)
  • ENSMUSP00000081006 (10090)
  • ENSRNOP00000002593 (10116)
  • ENSMMUP00000037287 (9544)
  • ENSP00000383365 (9606)
  • YPL091W (4932)
  • SPBC17A3.07 (4896)

    • Note: Wrong gene symbol in GenAge.

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