HMOX1

Symbol: HMOX1
Name: heme oxygenase (decycling) 1
Entrez gene ID: 3162
Ensembl gene ID: ENSG00000100292
Species: Human (Taxid: 9606)


Observation:

A (GT)n repeat polymorphism in the promoter region of the human HO-1 gene was examined in younger (60 years, 59 male and 45 female) and older (60-75 years, 95 male and 106 female) subjects. The proportion of allelic frequencies in class L with a large size of (GT)n repeat, as well as the genotypic frequencies in group I with class L alleles, was significantly lower in the oldest male subjects than in the younger males. In contrast, in the oldest female subjects this was not observed [12566526].HMOX1 was found to be associated with longevity [12566526].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • HMOX1 (GT)_n repeats 0.0027 [12566526]

  • Classification:
  • Longevity-Associated


  • Type:
  • Gene
  • Protein coding

    References:
  • 12566526: Relationship between microsatellite polymorphism in the haem oxygenase-1 gene promoter and longevity of the normal Japanese population.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • HMOX1 (9606)
  • HMOX1 (9598)
  • HMOX1 (9615)
  • HMOX1 (9913)
  • Hmox1 (10090)
  • Hmox1 (10116)
  • HMOX1 (9031)
  • hmox1 (7955)

  • Inparanoids
  • ENSMUSP00000005548 (10090)
  • ENSRNOP00000019192 (10116)
  • ENSMMUP00000037050 (9544)
  • YLR205C (4932)



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